Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar 17;4(2):450-453.
doi: 10.1002/jha2.676. eCollection 2023 May.

Erythroleukemia: Classification

Nathalie Cervera  1 , Arnaud Guille  1 , José Adélaïde  1 , Marie-Anne Hospital  2 , Sylvain Garciaz  2 , Marie-Joelle Mozziconacci  3 , Norbert Vey  2 , Véronique Gelsi-Boyer  1   3 , Daniel Birnbaum  1
Affiliations

Erythroleukemia: Classification

Nathalie Cervera et al. EJHaem. .

Abstract

Acute erythroid leukemia (AEL) is a rare (2%-5%) form of acute myeloid leukemia (AML). Molecular alterations found in AEL resemble those of other AMLs. We report a classification of AELs in three major classes, with different prognosis and some specific features such as a tendency to mutual exclusion of mutations in epigenetic regulators and signaling genes.

Keywords: TP53; acute erythroid leukemia; molecular classification; mutations.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic representation of the combination of the main driver mutations occurring in acute erythroid leukemia (AEL). AEL cases are classified into three major classes according to alterations in driver genes (listed at the right and in Table S2) grouped according to their function.
FIGURE 2
FIGURE 2
Overall survival of the acute erythroid leukemia (AEL) cohort according to molecular classification. (1) Kaplan–Meier curves show the different outcomes of the three major classes. The three classes have different prognosis, with class 1 the best and class 3 the worst. (2) Kaplan–Meier curves show the different outcomes of class 2 and class 3 with either epigenetic or signaling. Class 2 cases with epigenetic mutations tend to have a poorer outcome than class 2 cases with signaling mutations.
See this image and copyright information in PMC

References

    1. Jaffe ES, Harris NL, Stein H, Vardiman J. World Health Organization classification of tumours pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2001.
    1. Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391–405. - PubMed
    1. Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, et al. The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic/dendritic neoplasms. Leukemia. 2022;36(7):1703–19. - PMC - PubMed
    1. Grossmann V, Bacher U, Haferlach C, Schnittger S, Pötzinger F, Weissmann S, et al. Acute erythroid leukemia (AEL) can be separated into distinct prognostic subsets based on cytogenetic and molecular genetic characteristics. Leukemia. 2013;27(9):1940–3. - PubMed
    1. Cervera N, Carbuccia N, Garnier S, Guille A , Adélaïde J, Murati A, et al. Molecular characterization of acute erythroid leukemia (M6‐AML) using targeted next‐generation sequencing. Leukemia. 2016. 30(4):966–70. - PubMed