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Comment
. 2023 May 18;83(10):1544-1546.
doi: 10.1016/j.molcel.2023.04.028.

Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics

Billy Wai-Lung Ng  1 , Tongyang Xu  2 , Zhihao Guo  2
Affiliations
Comment

Discovery of chemical probes that perturb protein complexes using size exclusion chromatography and chemical proteomics

Billy Wai-Lung Ng et al. Mol Cell. .

Abstract

Most human proteins lack small-molecule ligands, rendering these proteins "undruggable." In this issue of Molecular Cell, Lazear et al.1 develop a novel chemical proteomic screening platform and discover new chemical probes targeting previously undruggable protein complexes.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Proteomic discovery of chemical probes that perturb protein complexes in human cells.
    Lazear MR, Remsberg JR, Jaeger MG, Rothamel K, Her HL, DeMeester KE, Njomen E, Hogg SJ, Rahman J, Whitby LR, Won SJ, Schafroth MA, Ogasawara D, Yokoyama M, Lindsey GL, Li H, Germain J, Barbas S, Vaughan J, Hanigan TW, Vartabedian VF, Reinhardt CJ, Dix MM, Koo SJ, Heo I, Teijaro JR, Simon GM, Ghosh B, Abdel-Wahab O, Ahn K, Saghatelian A, Melillo B, Schreiber SL, Yeo GW, Cravatt BF. Lazear MR, et al. Mol Cell. 2023 May 18;83(10):1725-1742.e12. doi: 10.1016/j.molcel.2023.03.026. Epub 2023 Apr 20. Mol Cell. 2023. PMID: 37084731 Free PMC article.

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