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. 2023 Jun 12;41(6):1006-1008.
doi: 10.1016/j.ccell.2023.04.013. Epub 2023 May 18.

Hot on the trail in the TME: Clues from a trilogy of checkpoint inhibitor trials in nasopharyngeal cancer

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Hot on the trail in the TME: Clues from a trilogy of checkpoint inhibitor trials in nasopharyngeal cancer

Brigette B Y Ma et al. Cancer Cell. .
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Abstract

In this issue of Cancer Cell, Yang et al. report the third in a series of phase III trials that demonstrates the survival benefit of combining a PD-1 inhibitor with chemotherapy in nasopharyngeal cancer. A gene expression analysis identifies "hot" and "cold" tumor signatures with prognostic and predictive significance.

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Conflict of interest statement

Declaration of interests B.B.Y.M. is on the advisory board of Beigene, Singapore and a consultant for Alentis and Viracta Therapeutics. B.B.Y.M. received research grants from Bristol-Myers Squibb (BMS) and Merck Sharp & Dohme (MSD). Q.T.L. serves as an unpaid member of the Head and Neck Scientific Advisory Committee for Merck Research Laboratory.

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