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. 2023 Apr;509(1):140-144.
doi: 10.1134/S0012496623700278. Epub 2023 May 19.

Brain D2-Like Dopamine Receptor Distribution in Rats with Different Types of Genetic Epilepsy

E T Tsyba  1 , L M Birioukova  2 , I S Midzyanovskaya  2 , N M Surina  3 , K R Abbasova  3
Affiliations

Brain D2-Like Dopamine Receptor Distribution in Rats with Different Types of Genetic Epilepsy

E T Tsyba et al. Dokl Biol Sci. 2023 Apr.

Abstract

The distribution of the D2-like dopamine receptor (D2DR) in the cortex and striatum was compared between rats with absence, audiogenic, or combined genetically determined epilepsy and normal Wistar rats by autoradiography. A significantly lower D2DR binding density was observed in the dorsal and ventrolateral aspects of the nucleus accumbens in epileptic vs. non-epileptic rats. Rats with audiogenic epilepsy additionally showed a higher D2DR density in the dorsal striatum and motor and somatosensory cortex and a lower D2DR density in the ventrolateral part of the nucleus accumbens. The findings indicated that a common neuronal circuit is involved in the pathogenesis of both convulsive and nonconvulsive forms of generalized epilepsy.

Keywords: KM; WAG/Rij; absence epilepsy; audiogenic epilepsy; autoradiography; dopamine; neurotransmitter.

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References

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