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Review
. 2023 May 19;24(1):137.
doi: 10.1186/s12882-023-03185-3.

Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature

Fatma El-Husseiny Moustafa  1 , Eman Nagy  2 , Salwa Mahmoud Elwasif  3 , Mohamed Sobh  3
Affiliations
Review

Karyomegalic interstitial nephritis as a rare cause of kidney graft dysfunction: case report and review of literature

Fatma El-Husseiny Moustafa et al. BMC Nephrol. .

Abstract

Karyomegalic interstitial nephritis (KIN) is a rare cause of chronic interstitial nephritis characterized by enlarged renal tubular epithelial nuclei. The first case of KIN reported in a kidney graft was in 2019. Here, we report the first case of KIN in 2 brothers receiving kidneys from 2 different unrelated living donors. A male kidney transplant recipient with focal segmental glomerulosclerosis as the original kidney disease presented with graft impairment and proteinuria, and graft biopsy revealed KIN. This patient had a brother who was also a kidney transplant recipient and had one episode of graft impairment and was diagnosed with KIN as well.

Keywords: Interstitial nephritis; Karyomegalic interstitial nephritis; Kidney transplantation.

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Conflict of interest statement

No competing interests

Figures

Fig. 1
Fig. 1
a: Focal segmental glomerulosclerosis. (Hx&EX 400). b: The other glomeruli show only detached podocytes
Fig. 2
Fig. 2
a: Glomeruli show aneurysmally dilated capillaries (HX&Ex400). b: Dense lymphocytic infiltrate (HX&Ex100). c&d: Tubular cells have large nuclei. No tubulitis (t0) inspite of the marked dense interstitial infiltrate (i3)
Fig. 3
Fig. 3
a: Detached podocytes. b: Lamellated basement membranes. c: Thinning & thickening of basement membranes
Fig. 4
Fig. 4
a: Dense lymphocytic infiltrate (i3), acute tubular injury. (HX&Ex200). b&c: Tubular cells have large nuclei (HX&Ex200)
See this image and copyright information in PMC

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