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. 2024 Oct;18(5):1657-1664.
doi: 10.1007/s11764-023-01405-1. Epub 2023 May 20.

Benign and malignant pulmonary parenchymal findings on chest CT among adult survivors of childhood and young adult cancer with a history of chest radiotherapy

Dana Barnea  1 , Emily S Tonorezos  2 , Amber Khan  3 , Joanne F Chou  4 , Chaya S Moskowitz  4 , Rana Kaplan  5 , Suzanne L Wolden  6 , Yolanda Bryce  7 , Kevin C Oeffinger  8
Affiliations

Benign and malignant pulmonary parenchymal findings on chest CT among adult survivors of childhood and young adult cancer with a history of chest radiotherapy

Dana Barnea et al. J Cancer Surviv. 2024 Oct.

Abstract

Purpose: Childhood and young adult cancer survivors exposed to chest radiotherapy are at increased risk of lung cancer. In other high-risk populations, lung cancer screening has been recommended. Data is lacking on prevalence of benign and malignant pulmonary parenchymal abnormalities in this population.

Methods: We conducted a retrospective review of pulmonary parenchymal abnormalities in chest CTs performed more than 5 years post-cancer diagnosis in survivors of childhood, adolescent, and young adult cancer. We included survivors exposed to radiotherapy involving the lung field and followed at a high-risk survivorship clinic between November 2005 and May 2016. Treatment exposures and clinical outcomes were abstracted from medical records. Risk factors for chest CT-detected pulmonary nodule were assessed.

Results: Five hundred and ninety survivors were included in this analysis: median age at diagnosis, 17.1 years (range, 0.4-39.8); and median time since diagnosis, 22.3 years (range, 1-58.6). At least one chest CT more than 5 years post-diagnosis was performed in 338 survivors (57%). Among these, 193 (57.1%) survivors had at least one pulmonary nodule detected on a total of 1057 chest CTs, resulting in 305 CTs with 448 unique nodules. Follow-up was available for 435 of these nodules; 19 (4.3%) were malignant. Risk factors for first pulmonary nodule were older age at time of CT, CT performed more recently, and splenectomy.

Conclusions: Benign pulmonary nodules are very common among long-term survivors of childhood and young adult cancer.

Implications for cancer survivors: High prevalence of benign pulmonary nodules in cancer survivors exposed to radiotherapy could inform future guidelines on lung cancer screening in this population.

Keywords: Cancer survivor; Chest CT; Lung cancer; Pulmonary nodule.

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Conflict of interest statement

Conflict of interest Authors Dana Barnea, Emily S. Tonorezos, Amber Khan, Joanne F. Chou, Chaya S. Moskowitz, Rana Kaplan, and Suzanne L. Wolden declare they have no financial interests. Author Kevin C. Oeffinger is on the advisory board of Grail, LLC. Author Yolanda Bryce is a consultant for Hologic, Inc. and speaker for Boston Scientific and Pfizer, Canada.

Figures

Fig. 1
Fig. 1
Proportion of first pulmonary nodule on chest CT by time since primary cancer diagnosis in adult survivors of childhood and young adult cancer exposed to chest radiation
See this image and copyright information in PMC

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