Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep;48(9):2881-2894.
doi: 10.1007/s11064-023-03945-5. Epub 2023 May 20.

Aβ Induces Neuroinflammation and Microglial M1 Polarization via cGAS-STING-IFITM3 Signaling Pathway in BV-2 Cells

Zheng Wu  1 , Wei Tang  2 , Fatima Elzahra E M Ibrahim  1 , Xuejing Chen  1 , Hongting Yan  1 , Chunmei Tao  1 , Zhiming Wang  1 , Yunchu Guo  1 , Yu Fu  1 , Qi Wang  3 , Yusong Ge  4
Affiliations

Aβ Induces Neuroinflammation and Microglial M1 Polarization via cGAS-STING-IFITM3 Signaling Pathway in BV-2 Cells

Zheng Wu et al. Neurochem Res. 2023 Sep.

Abstract

Microglia, innate immune cells of the brain, constantly monitor the dynamic changes of the brain microenvironment under physiological conditions and respond in time. Growing evidence suggests that microglia-mediated neuroinflammation plays an important role in the pathogenesis of Alzheimer's disease. In this study, we investigated that the expression of IFITM3 was significantly upregulated in microglia under the Aβ treatment, and knockdown of IFITM3 in vitro suppressed the M1-like polarization of microglia. Moreover, IFITM3 was regulated by cGAS-STING signaling in activated microglia, and inhibition of cGAS-STING signaling reduces IFITM3 expression. Taken together, our findings suggested that the cGAS-STING-IFITM3 axis may be involved in Aβ-induced neuroinflammation in microglia.

Keywords: Alzheimer's disease; IFITM3; Neuroinflammation; cGAS-STING.

PubMed Disclaimer

References

    1. Scheltens P, Blennow K, Breteler MM et al (2016) Alzheimer’s disease. Lancet 388(10043):505–517. https://doi.org/10.1016/S0140-6736(15)01124-1 - DOI - PubMed
    1. Selkoe DJ (2001) Alzheimer’s disease: genes, proteins, and therapy. Physiol Rev 81(2):741–766. https://doi.org/10.1152/physrev.2001.81.2.741 - DOI - PubMed
    1. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science 297(5580):353–356. https://doi.org/10.1126/science.1072994 - DOI - PubMed
    1. Ozben T, Ozben S (2019) Neuro-inflammation and anti-inflammatory treatment options for Alzheimer’s disease. Clin Biochem 72:87–89. https://doi.org/10.1016/j.clinbiochem.2019.04.001 - DOI - PubMed
    1. D’Andrea MR, Cole GM, Ard MD (2004) The microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol Aging 25(5):675–683. https://doi.org/10.1016/j.neurobiolaging.2003.12.026 - DOI - PubMed

MeSH terms

LinkOut - more resources