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Randomized Controlled Trial
. 2023 May 20;23(1):170.
doi: 10.1186/s12871-023-02143-8.

Postoperative effect of sufentanil preemptive analgesia combined with psychological intervention on breast cancer patients

Hong Tan #  1 , Chengqiang Wang #  2 , Yihong Jiang  1 , Quan Shi  1 , Wei Liang  1 , Di Li  3
Affiliations
Randomized Controlled Trial

Postoperative effect of sufentanil preemptive analgesia combined with psychological intervention on breast cancer patients

Hong Tan et al. BMC Anesthesiol. .

Abstract

Objectives: To explore the postoperative effects of sufentanil preemptive analgesia combined with psychological intervention on breast cancer patients undergoing radical surgery.

Methods: 112 female breast cancer patients aged 18-80 years old who underwent radical surgery by the same surgeon were randomly divided into 4 groups, and there were 28 patients in each group. Patients in group A were given 10 µg sufentanil preemptive analgesia combined with perioperative psychological support therapy (PPST), group B had only 10 µg sufentanil preemptive analgesia, group C had only PPST, and group D were under general anesthesia with conventional intubation. Visual analogue scoring (VAS) was used for analgesic evaluation at 2, 12 and 24 h after surgery and compared among the four groups by ANOVA method.

Results: The awakening time of patients in group A or B was significantly shorter than that in group C or D, and the awakening time in group C was significantly shorter than that in group D. Moreover, patients in group A had the shortest extubation time, while the group D had the longest extubation time. The VAS scores at different time points showed significant difference, and the VAS scores at 12 and 24 h were significantly lower than those at 2 h (P < 0.05). The VAS scores and the changing trend of VAS scores were varied among the four groups (P < 0.05). In addition, we also found that patients in group A had the longest time to use the first pain medication after surgery, while patients in group D had the shortest time. But the adverse reactions among the four groups showed no difference.

Conclusions: Sufentanil preemptive analgesia combined with psychological intervention can effectively relieve the postoperative pain of breast cancer patients.

Keywords: Breast cancer patients; Preoperative analgesia; Psychological intervention; Sufentanil.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Comparison of age (A), body weight (B), and remifentanil dosage (C) of breast cancer patients in the four groups
Fig. 2
Fig. 2
Comparison of surgery time (A), awakening time (B), and extubation time (C) of breast cancer patients in the four groups undergoing surgery
Fig. 3
Fig. 3
Comparison of VAS scores (A), and time to use the first pain medication (B) of breast cancer patients in the four groups after surgery
See this image and copyright information in PMC

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