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Meta-Analysis
. 2023 May 20;23(1):279.
doi: 10.1186/s12905-023-02412-1.

Knowledge, attitude, and uptake of human papillomavirus vaccine among adolescent schoolgirls in Ethiopia: a systematic review and meta-analysis

Dagne Addisu  1 , Natnael Atnafu Gebeyehu  2 , Yismaw Yimam Belachew  3
Affiliations
Meta-Analysis

Knowledge, attitude, and uptake of human papillomavirus vaccine among adolescent schoolgirls in Ethiopia: a systematic review and meta-analysis

Dagne Addisu et al. BMC Womens Health. .

Abstract

Background: Cervical cancer is an international public health issue. Nearly all cases of cervical cancer are caused by the human papillomavirus. The HPV vaccine prevents more than 75% of cervical cancer. The extent to which adolescent girls' knowledge and uptake of the HPV vaccine have to be investigated in order to build effective promotion strategies and increase the uptake of the vaccine. The evidence that is currently available in this area is controversial and inconclusive. Hence, this study has estimated the pooled proportion of good knowledge, positive attitude, and uptake of the HPV vaccine and its associated factors among adolescent schoolgirls in Ethiopia.

Methods: PubMed, Google Scholar, AJOL, ScienceDirect, and DOAJ were used to search relevant studies. A total of 10 studies were included. The data were extracted by two reviewers using Microsoft Excel and exported to STATA Version 17 for analysis. A random effects model was applied during the analysis. Heterogeneity and publication bias across the studies were evaluated using I2 statistics and Egger's test, respectively. The PROSPERO registration number for the review is CRD42023414030.

Result: A total of eight studies comprising 3936 study participants for knowledge and attitude and five studies with 2,481 study participants for uptake of HPV were used to estimate the pooled proportions of good knowledge, a positive attitude, and uptake of the HPV vaccine, respectively. The pooled proportions of good knowledge, positive attitude, and uptake of the HPV vaccine were 55.12%, 45.34%, and 42.05%, respectively. Being an urban resident (OR = 4.17, 95% CI = 1.81, 9.58), having good knowledge (OR = 6.70, 95% CI = 3.43, 13.07), and a positive attitude (OR = 2.04, 95% CI = 1.51, 2.74), were significantly associated with the uptake of the vaccine.

Conclusion: The pooled proportions of good knowledge, a positive attitude, and uptake of the HPV vaccine were low in Ethiopia. Being an urban resident and having good knowledge and a positive attitude towards the HPV vaccine were significantly associated with the uptake of the HPV vaccine. We recommend increasing adolescent knowledge, positive attitudes, and uptake of HPV vaccination through school-based seminars, health education, and community mobilization.

Keywords: Adolescents; Attitude; Ethiopia; HPV vaccine; Knowledge; Uptake.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Schematic presentation of study selection for systematic review and meta-analysis of knowledge, attitude, and uptake of HPV vaccine and associated factors among adolescent schoolgirls in Ethiopia
Fig. 2
Fig. 2
Pooled level of good knowledge about HPV vaccine among adolescent schoolgirls
Fig. 3
Fig. 3
Pooled level of positive attitude about HPV vaccine among adolescent schoolgirls in Ethiopia
Fig. 4
Fig. 4
Pooled coverage of HPV vaccine uptake among adolescent schoolgirls in Ethiopia
Fig. 5
Fig. 5
Forest plot for the association of urban resident with the uptake of HPV vaccine among adolescent schoolgirls in Ethiopia
Fig. 6
Fig. 6
Forest plot for the association of positive attitude about HPV vaccine with the uptake of the vaccine among adolescent schoolgirls in Ethiopia
Fig. 7
Fig. 7
Forest plot for the association of good knowledge about HPV with the uptake of the vaccine among adolescent schoolgirls in Ethiopia
See this image and copyright information in PMC

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