Stress, diet, exercise: Common environmental factors and their impact on epigenetic age
- PMID: 37211319
- DOI: 10.1016/j.arr.2023.101956
Stress, diet, exercise: Common environmental factors and their impact on epigenetic age
Abstract
Epigenetic aging clocks have gained significant attention as a tool for predicting age-related health conditions in clinical and research settings. They have enabled geroscientists to study the underlying mechanisms of aging and assess the effectiveness of anti-aging therapies, including diet, exercise and environmental exposures. This review explores the effects of modifiable lifestyle factors' on the global DNA methylation landscape, as seen by aging clocks. We also discuss the underlying mechanisms through which these factors contribute to biological aging and provide comments on what these findings mean for people willing to build an evidence-based pro-longevity lifestyle.
Keywords: Aging; Aging clocks; Epigenetics; Longevity; Machine learning; Nutrition.
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Conflict of interest statement
Declaration of Competing Interest AZ and FG are employed at Deep Longevity, a wholly-owned subsidiary of Endurance Longevity (SEHK:0575. HK), a publicly traded company. DK was a Deep Longevity employee at the time the first draft was written.
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