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. 2023 Aug;16(8):e015282.
doi: 10.1161/CIRCIMAGING.123.015282. Epub 2023 May 22.

68Ga-Dotatate Hybrid Positron Emission Tomography/Magnetic Resonance Imaging for Noninvasive Early Detection of Heart Transplant Rejection

Ana Devesa  1   2   3 , Philip M Robson  1 , Renata Pyzik  1 , Adam Jacobi  4 , Munir Ghesani  5 , Anelechi Anyanwu  6 , Donna Mancini  3 , Zahi A Fayad  1 , Maria Giovanna Trivieri  1   3
Affiliations

68Ga-Dotatate Hybrid Positron Emission Tomography/Magnetic Resonance Imaging for Noninvasive Early Detection of Heart Transplant Rejection

Ana Devesa et al. Circ Cardiovasc Imaging. 2023 Aug.
No abstract available

Keywords: 68Ga-Dotatate; PET/MR; heart transplant; rejection.

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Conflict of interest statement

Disclosures None.

Figures

Figure 1.
Figure 1.. 68Ga-Dotatate-PET/MR imaging in rejection patients versus control
Representative examples of 68Ga-Dotatate-PET/MR imaging in heart transplant patients with (A and B) and without rejection (control, C). Panels show fused PET/MR imaging, and T2 mapping polar map is represented for each patient (T2 values are represented in milliseconds; reference values for T2 mapping are detailed in Supplemental Material). A) shows 68Ga-Dotatate uptake in the basal anteroseptum in a patient with allograft rejection (arrows), colocalizing with an increased T2 time in basal anteroseptum, but with normal average T2 values; B) shows 68Ga-Dotatate uptake in the inferior wall (arrows), colocalizing with abnormal T2 values, in a patient with allograft rejection; C) shows the absence of 68Ga-Dotatate uptake in a patient with a heart transplant and no signs of rejection. Please note abnormal T2 values in mid anterolateral wall and apical segments.
Figure 2.
Figure 2.. Positive 68Ga-Dotatate-PET/MR imaging in a biopsy-negative rejection patient
Representative examples of fused 68Ga-Dotatate-PET/MR imaging. The baseline scan was performed after completing treatment for rejection and showed no evident visual 68Ga-Dotatate uptake. The recurrence of heart failure symptoms after 6 weeks led to a follow-up PET/MR (follow-up scan), which showed increased 68Ga-Dotatate uptake in the interatrial septum reaching for the atrioventricular junction and in the left lateral ventricular wall (arrows). This patient subsequently developed a complete heart block, likely secondary to the involvement of the atrioventricular junction.
See this image and copyright information in PMC

References

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    1. Aparici CM, Narula J, Puig M, Camprecios M, Martín JC, Tembl A, Flotats A, Estorch M, Catafau AM, Bernà L, et al. Somatostatin receptor scintigraphy predicts impending cardiac allograft rejection before endomyocardial biopsy. Eur J Nucl Med. 2000;27:1754–1759. - PubMed

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