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Review
. 2023 May;95(5):e28773.
doi: 10.1002/jmv.28773.

Today's Kaposi sarcoma is not the same as it was 40 years ago, or is it?

Blossom Damania  1 , Dirk P Dittmer  1
Affiliations
Review

Today's Kaposi sarcoma is not the same as it was 40 years ago, or is it?

Blossom Damania et al. J Med Virol. 2023 May.

Abstract

This review will provide an overview of the notion that Kaposi sarcoma (KS) is a disease that manifests under diverse and divergent circumstances. We begin with a historical introduction of KS and KS-associated herpesvirus (KSHV), highlight the diversity of clinical presentations of KS, summarize what we know about the cell of origin for this tumor, explore KSHV viral load as a potential biomarker for acute KSHV infections and KS-associated complications, and discuss immune modulators that impact KSHV infection, KSHV persistence, and KS disease.

Keywords: KSHV; Kaposi sarcoma; herpesvirus.

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Conflict of interest statement

Conflict of Interest

The authors declare no conflicts.

Figures

Figure 1
Figure 1
A. Picture of KS lesions in the lung. Arrows indicate a nodular lesion (N) and a flat lesion (F). B. Distribution of KSHV plasma viral loads (DNA genome copies/ml) in a cohort of 29 PLWH on successful cART presenting with KS requiring cancer therapy (data from ).
See this image and copyright information in PMC

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