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Review
. 2023 Apr 15;12(2):23-41.
eCollection 2023.

Parkinson's genetics research on underrepresented AfrAbia populations: current state and future prospects

Wael Mohamed  1
Affiliations
Review

Parkinson's genetics research on underrepresented AfrAbia populations: current state and future prospects

Wael Mohamed. Am J Neurodegener Dis. .

Abstract

Parkinson's disease (PD), the most common motoric neurodegenerative illness, has been extensively researched to better understand its complex pathophysiology. Nearly 80% of genome-wide association studies have been conducted on persons of European ancestry, indicating a lack of diversity in human genetics. Disparate representation may result in disparities that impede the equitable adoption of personalized medicine and may also limit our knowledge of illness etiology. Even though Parkinson's disease (PD) is a global affliction, the AfrAbia population remains understudied. We conducted a dynamic and longitudinal bibliometric analysis to investigate existing studies on Parkinson's disease genetics in the AfrAbia area and identify data gaps and possible new research avenues. All PD papers concentrating on PD genetics were found using the search terms "Parkinson's Disease", "Genetics", and "Africa" in the PubMed/MEDLINE database. Only English publications published between 1992 and 2023 were chosen using filters. Original English-language research publications disclosing genetic results on Parkinson's disease in non-European Africans were examined for inclusion. Two sets of independent reviewers discovered and extracted pertinent data. The bibliometric study was carried out using the R software packages Bibliometrix and Biblioshiny. The narrowed search yielded 43 publications, all published between 2006 and 2022. Yet, after applying filters and considering the inclusion requirements, the search results comprise just 16 original articles out of 43 articles. There were 27 articles eliminated. This study puts emphasis on the critical need for more diverse participant demographics in Parkinson's disease investigations. AfrAbia-PD-Genetic Consortium (AAPDGC) is GP2 initiative that helps to represent AfrAbia PD genetics.

Keywords: AfrAbia; AfrAbia-PD-Genetic Consortium (AAPDGC); Parkinson’s disease; bibliometric analysis; challenges; genetic; genome wide association study.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Annual scientific production regarding PD genetic studies in Africa from 2006-2022.
Figure 2
Figure 2
Source growth regarding PD genetic studies in Africa from 2006-2022.
Figure 3
Figure 3
Word Growth regarding PD genetic studies in Africa from 2006-2022.
Figure 4
Figure 4
Keyword co-occurrence regarding PD genetic studies in Africa from 2006-2022.
Figure 5
Figure 5
Country collaboration regarding PD genetic studies in Africa from 2006-2022.
See this image and copyright information in PMC

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References

    1. Karlsen KH, Tandberg E, Årsland D, Larsen JP. Health related quality of life in Parkinson’s disease: a prospective longitudinal study. J Neurol Neurosurg Psychiatry. 2000;69:584–589. - PMC - PubMed
    1. Global Parkinson’s Disease Survey (GPDS) Steering Committee. Factors impacting on quality of life in Parkinson’s disease: results from an international survey. Mov Disord. 2002;17:60–67. - PubMed
    1. Huang Z, de la Fuente-Fernandez R, Stoessl AJ. Etiology of Parkinson’s disease. Can J Neurol Sci. 2003;30(Suppl 1):S10–S18. - PubMed
    1. Heligman L, Chen N, Babakol O. Shifts in the structure of population and deaths in less developed regions. In: Gribble JN, Preston SH, editors. The Epidemiological Transition. Policy and Planning Implications for Developing Countries. Washington, DC: National Academy Press; 2000. pp. 9–41.
    1. Shulman JM, De Jager PL, Feany MB. Parkinson’s disease: genetics and pathogenesis. Annu Rev Pathol. 2011;6:193–222. - PubMed

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