Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Apr 18;15(4):e37762.
doi: 10.7759/cureus.37762. eCollection 2023 Apr.

Surgical Treatment of Penile Verrucous Squamous Cell Carcinoma in an HIV-Infected Patient: A Case Report

Yacoub A Okieh  1   2 , Craig Aurtz Tombet  1   2 , Anouar El Moudane  1   2 , Yousef Kouiss  1   2 , Ali Barki  1   2
Affiliations
Case Reports

Surgical Treatment of Penile Verrucous Squamous Cell Carcinoma in an HIV-Infected Patient: A Case Report

Yacoub A Okieh et al. Cureus. .

Abstract

Although uncommon, penile carcinoma can be a debilitating disease with various causes, and cancer is a significant contributor to morbidity and mortality in individuals infected with HIV. Verrucous carcinoma, a subtype of epidermoid carcinoma, is typically slow-growing and has a low propensity to metastasize. We present a case study of a 55-year-old HIV-positive patient with a massive squamous cell carcinoma of the penis that had been developing for over two years. To treat the condition, the patient underwent a total penectomy, perineal urethrostomy, and bilateral inguinal lymphadenectomy.

Keywords: human immunodeficiency virus; infection; surgery; total penectomy; verrucous carcinoma.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Penile mass on physical examination.
Figure 2
Figure 2. CT scan of the thorax, abdomen, and pelvis revealed bilateral inguinal lymphadenopathies.
Figure 3
Figure 3. The surgical area after total penectomy and perineal urethrostomy were performed.
Figure 4
Figure 4. H&E-stained sections of the defects revealed squamous cell carcinoma with signs of keratinization.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Penile cancer: epidemiology, pathogenesis and prevention. Bleeker MC, Heideman DA, Snijders PJ, Horenblas S, Dillner J, Meijer CJ. World J Urol. 2009;27:141–150. - PubMed
    1. Incidence trends in primary malignant penile cancer. Barnholtz-Sloan JS, Maldonado JL, Pow-sang J, Giuliano AR. https://doi.org/10.1016/j.urolonc.2006.08.029. Urol Oncol. 2007;25:361–367. - PubMed
    1. EAU penile cancer guidelines 2009. Pizzocaro G, Algaba F, Horenblas S, Solsona E, Tana S, Van Der Poel H, Watkin NA. Eur Urol. 2010;57:1002–1012. - PubMed
    1. Associated risk factors of STIs and multiple sexual relationships among youths in Malawi. Wilson CN, Sathiyasusuman A. PLoS One. 2015;10:0. - PMC - PubMed
    1. HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis. Stankiewicz E, Kudahetti SC, Prowse DM, et al. Mod Pathol. 2009;22:1160–1168. - PubMed

Publication types

LinkOut - more resources