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[Preprint]. 2023 May 9:rs.3.rs-2547252.
doi: 10.21203/rs.3.rs-2547252/v1.

Adverse Childhood Experiences and Prescription Opioid Use During Pregnancy: An Analysis of the North and South Dakota PRAMS, 2019-2020

Alexander Testa  1 , Benjamin Jacobs  2 , Lixia Zhang  3 , Dylan Jackson  4 , Kyle Ganson  5 , Jason Nagata  6
Affiliations

Adverse Childhood Experiences and Prescription Opioid Use During Pregnancy: An Analysis of the North and South Dakota PRAMS, 2019-2020

Alexander Testa et al. Res Sq. .

Update in

Abstract

Objectives: This study assesses the association between adverse childhood experiences (ACEs) and prescription opioid use during pregnancy. Methods: This study uses data on 2,999 individuals from the 2019 and 2020 Pregnancy Risk Assessment Monitoring System (PRAMS) from North Dakota and South Dakota. The relationship between ACEs and prescription opioid use during pregnancy is examined using multiple logistic regression. Results: The prevalence of prescription opioid use increases alongside accumulating ACEs. Compared to those with no ACEs, recent mothers with three or more ACEs have a 2.4 greater odds of prescription opioid use during pregnancy (aOR [adjusted odds ratio] = 2.437; 95% CI [confidence interval] = 1.319, 4.503). Conclusion: Accumulating ACEs are associated with an increased risk of prescription opioid use during pregnancy. Additional research is needed better understand the mechanisms that link ACEs and prescription opioid use during pregnancy, as well as how to best support those with ACEs exposure in a trauma-informed manner to reduce the risk of substance use.

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Conflict of interest statement

Competing interests

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1. Prevalence of Prescription Opioid Use During Pregnancy by Number of ACEs (N = 2,999)
Note: rests of a χ2 with 3 degrees of freedom shows a statistically significant difference between prescription opioid use during pregnancy across the number of ACEs (χ2 = 37.69, p <.001)
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