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Review
. 2023 May 5:11:1087337.
doi: 10.3389/fcell.2023.1087337. eCollection 2023.

Oncogenic roles and related mechanisms of the long non-coding RNA MINCR in human cancers

Ce Chao  1 , Renzhe Tang  1 , Jiamin Zhao  2 , Dongmei Di  1 , Yongxiang Qian  1 , Bin Wang  1
Affiliations
Review

Oncogenic roles and related mechanisms of the long non-coding RNA MINCR in human cancers

Ce Chao et al. Front Cell Dev Biol. .

Abstract

Long non-coding RNAs (lncRNAs) play vital roles in regulating epigenetic mechanisms and gene expression levels, and their dysregulation is closely associated with a variety of diseases such as cancer. Several studies have demonstrated that lncRNAs are dysregulated during tumor progression. Recently, the MYC-induced long non-coding RNA MINCR, a newly identified lncRNA, has been demonstrated to act as an oncogene in different cancers, including gallbladder cancer, hepatocellular cancer, colorectal cancer, non-small cell lung cancer, oral squamous cell carcinoma, nasopharyngeal cancer, and glioma. Moreover, MINCR has been reported to act as a biomarker in the prognosis of patients with different cancers. In this review, we summarize and analyze the oncogenic roles of MINCR in a variety of human cancers in terms of its clinical significance, biological functions, cellular activities, and regulatory mechanism. Our analysis of the literature suggests that MINCR has potential as a novel biomarker and therapeutic target in human cancers.

Keywords: MINCR; biomarker; human cancers; lncRNA; treatment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The function and regulating process of MINCR in multiple cancers.
FIGURE 2
FIGURE 2
The biological mechanisms of MINCR in cancers. The content of the black broken circle represents the hypothetical biological mechanism.
See this image and copyright information in PMC

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