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Review
. 2023 May 5:11:1168215.
doi: 10.3389/fcell.2023.1168215. eCollection 2023.

Advances in epidemiological status and pathogenesis of dental fluorosis

Kaiqiang Zhang  1 , Zhenfu Lu  1 , Xiaoying Guo  2
Affiliations
Review

Advances in epidemiological status and pathogenesis of dental fluorosis

Kaiqiang Zhang et al. Front Cell Dev Biol. .

Abstract

Fluoride is commonly consider as a "double-edged sword" because low consumption of fluoride can effectively prevent dental caries, but excessive consumption of fluoride can cause fluorosis. Dental fluorosis (DF) is a characteristic feature of fluorosis in the oral cavity that is manifested as tooth color changes and evident enamel defect. Presently, the pathogenesis of DF remains unclear. Herein, we have summarized the research progress in the pathogenesis and mechanism of DF in the past 5 years.

Keywords: dental fluorosis; epidemiology; molecular mechanism; pathogenesis; signal pathway.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Abanto Alvarez J., Rezende K. M., Marocho S. M., Alves F. B., Celiberti P., Ciamponi A. L. (2009). Dental fluorosis: Exposure, prevention and management. Med. Oral Patol. Oral Cir. Bucal 14 (2), E103–E107. 10.1159/000119520 - DOI - PubMed
    1. Adedara I. A., Abolaji A. O., Idris U. F., Olabiyi B. F., Onibiyo E. M., Ojuade T. D., et al. (2017). Neuroprotective influence of taurine on fluoride-induced biochemical and behavioral deficits in rats. Chem. Biol. Interact. 261, 1–10. 10.1016/j.cbi.2016.11.011 - DOI - PubMed
    1. Aguilar-Diaz F. D. C., Morales-Corona F., Cintra-Viveiro A. C., Fuente-Hernandez J. (2017). Prevalence of dental fluorosis in Mexico 2005-2015: A literature review. Salud Publica Mex. 59 (3), 306–313. 10.21149/7764 - DOI - PubMed
    1. Aulestia F. J., Groeling J., Bomfim G. H. S., Costiniti V., Manikandan V., Chaloemtoem A., et al. (2020). Fluoride exposure alters Ca(2+) signaling and mitochondrial function in enamel cells. Sci. Signal 13 (619). 10.1126/scisignal.aay0086 - DOI - PMC - PubMed
    1. Chang H., Wang Y., Liu H., Nan X., Wong S., Peng S., et al. (2017). Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis. Cell Death Dis. 8 (12), 3221. 10.1038/s41419-017-0078-4 - DOI - PMC - PubMed

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