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Review
. 2023 May 4:4:1159387.
doi: 10.3389/falgy.2023.1159387. eCollection 2023.

HIV-associated photodermatitis in African populations

Thuraya Isaacs  1 , Rannakoe Lehloenya  1
Affiliations
Review

HIV-associated photodermatitis in African populations

Thuraya Isaacs et al. Front Allergy. .

Abstract

Photosensitive dermatoses are seen in 5% of HIV-infected persons. These include drug- and chemical-induced photoallergic and phototoxic reactions, chronic actinic dermatitis of HIV, photo lichenoid drug eruptions, and porphyria. Data on photodermatitis in HIV are limited to case reports and series. The pathogenesis is not completely understood and includes a th2 phenotype in HIV which results in impaired barrier function and resultant allergen sensitisation as well as immune dysregulation. The objective of this manuscript is to review the literature on the clinical phenotype, pathogenesis, role of photo and patch testing, outcomes, and treatment of photodermatitis in HIV in an African population.

Keywords: HIV; actinic dermatitis; photodermatitis; photodermatoses; photosensitivity; pigmented skin.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Chronic actinic dermatitis of HIV in Fitzpatrick skin type IV showing a photodistributed eczematous eruption.
Figure 2
Figure 2
Chronic actinic dermatitis of HIV in Fitzpatrick skin type V with extension to non-sun exposed areas demonstrating hyperpigmentation and extensive depigmentation.
Figure 3
Figure 3
Efavirenz-associated reaction demonstrating in photodistributed indurated erythema with sharp cut off and annularity.
Figure 4
Figure 4
Efavirenz-associated reaction demonstrating in photodistributed indurated erythema with annularity of plaques and dusky centres.
Figure 5
Figure 5
Photolichenoid drug eruption to first line antituberculosis treatment demonstrating violaceous patches, plaques.
Figure 6
Figure 6
Photolichenoid drug eruption to first line antituberculosis treatment demonstrating violaceous patches and plaques with depigmentation.
Figure 7
Figure 7
Blisters, erosions, scarring and hyperpigmentation on the face of a patient with porphyria cutanea tarda.
Figure 8
Figure 8
Blisters, erosions, and scarring on the dorsa of the hand of a patient with porphyria cutanea tarda.
Figure 9
Figure 9
Casal's necklace as a manifestation of pellagra in an HIV-infected woman.
See this image and copyright information in PMC

References

    1. Bylaite M, Grigaitiene J, Lapinskaite GS. Photodermatoses: classification, evaluation and management. Br J Dermatol. 2009;161 Suppl 3:61–8. 10.1111/j.1365-2133.2009.09451.x - DOI - PubMed
    1. Bilu D, Mamelak AJ, Nguyen RH, Queiroz PC, Kowalski J, Morison WL, et al. Clinical and epidemiologic characterization of photosensitivity in HIV-positive individuals. Photodermatol Photoimmunol Photomed. 2004;20(4):175–83. 10.1111/j.1600-0781.2004.00101.x - DOI - PubMed
    1. Oakley AM, Badri T, Harris BW. Photosensitivity. Treasure Island, FL: StatPearls; (2022).
    1. Rathod DG, Muneer H, Masood S. Phototherapy. Treasure Island, FL: StatPearls; (2022). - PubMed
    1. Foering K, Chang AY, Piette EW, Cucchiara A, Okawa J, Werth VP. Characterization of clinical photosensitivity in cutaneous lupus erythematosus. J Am Acad Dermatol. 2013;69(2):205–13. 10.1016/j.jaad.2013.03.015 - DOI - PMC - PubMed

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