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. 2023 Apr 15;15(2):31-40.
eCollection 2023.

A randomized controlled trial to assess the effect of isotonic normal saline versus water post-Ryles Tube feeding for correcting hyponatremia among ICU patients at tertiary care hospital: a pilot study

Neetu Kataria  1 , Hoineiting Rebecca Haokip  2 , Vasantha C Kalyani  3
Affiliations

A randomized controlled trial to assess the effect of isotonic normal saline versus water post-Ryles Tube feeding for correcting hyponatremia among ICU patients at tertiary care hospital: a pilot study

Neetu Kataria et al. Int J Physiol Pathophysiol Pharmacol. .

Abstract

Objectives: To assess the effect of isotonic normal saline (NS) versus water post-Ryles Tube (RT) feeding upon hyponatremia and blood parameters in Intensive Care Units (ICU) admitted patients.

Methods: A parallel group randomized controlled trial design. The total sample size taken for this pilot trial was N = 50 as a thumb rule (n = 25 in each arm) selected by using a simple random sampling method. The sample was ICU-admitted patients with mild and moderate hyponatremia.at tertiary care hospital, Rishikesh. Intervention-20 mL Isotonic 0.9% normal saline (NS) among the experimental group vs. 20 mL water in the control group after each 9 am Ryles tube feeding respectively for three continuous days. At baseline and follow-up electrolytes, blood parameters, Glasgow Coma Scale (GCS), and blood pressures were assessed post-one hour of intervention daily for day-1, 2, 3 & 5. Data were analyzed by using descriptive & inferential statistics in the SPSS software 23.0 version.

Results: There was a significant difference found between the experimental and control groups for the post-test value of serum sodium levels, GCS, Systolic Blood Pressure, and Diastolic Blood Pressure (DBP) at day 1 of administration of normal saline intervention with p-value < 0.0001. However, it was found significant at day 5 between both groups for the above-mentioned variables.

Conclusion: The intervention of normal saline was found to be a cheaper and more effective remedy to treat hyponatremia and reduce mortality among ICU-admitted patients due to deterioration in bio-physiological parameters.

Keywords: Hyponatremia; Ryles tube feeding; intensive care unit; isotonic; normal saline.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
CONSORT chart.
Figure 2
Figure 2
Day-1 post-test Sodium levels positive correlation with GCS, chloride, DBP and negative correlation with SBP levels (N=50).
See this image and copyright information in PMC

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