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Comment
. 2023 Jul;23(7):412.
doi: 10.1038/s41577-023-00892-8.

Negative regulation of inflammasome activation in bats

Kirsty Minton  1
Affiliations
Comment

Negative regulation of inflammasome activation in bats

Kirsty Minton. Nat Rev Immunol. 2023 Jul.

Abstract

Ahn et al. show that bat ASC2 negatively regulates inflammasome activation, which could be exploited to inhibit inflammatory diseases in humans.

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Comment on

  • Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases.
    Ahn M, Chen VC, Rozario P, Ng WL, Kong PS, Sia WR, Kang AEZ, Su Q, Nguyen LH, Zhu F, Chan WOY, Tan CW, Cheong WS, Hey YY, Foo R, Guo F, Lim YT, Li X, Chia WN, Sobota RM, Fu NY, Irving AT, Wang LF. Ahn M, et al. Cell. 2023 May 11;186(10):2144-2159.e22. doi: 10.1016/j.cell.2023.03.036. Cell. 2023. PMID: 37172565

References

Original article

    1. Ahn M, et al. Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases. Cell. 2023 doi: 10.1016/j.cell.2023.03.036. - DOI - PubMed

Related article

    1. Wang L-F, et al. Decoding bat immunity: the need for a coordinated research approach. Nat. Rev. Immunol. 2021;21:269–271. doi: 10.1038/s41577-021-00523-0. - DOI - PMC - PubMed

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