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Review
. 2023 Sep;270(9):4354-4359.
doi: 10.1007/s00415-023-11765-4. Epub 2023 May 22.

Intravenous thrombolysis and mechanical recanalization for acute ischemic stroke in deep brain stimulation patients: a case series

Johannes Meyne #  1 , Mirjam Domschikowski #  1 , Johannes Hensler  2 , Ann-Kristin Helmers  3 , Daniela Berg  1 , Günther Deuschl  1 , Steffen Paschen  4
Affiliations
Review

Intravenous thrombolysis and mechanical recanalization for acute ischemic stroke in deep brain stimulation patients: a case series

Johannes Meyne et al. J Neurol. 2023 Sep.

Abstract

Background: Intravenous thrombolysis (IVT) and endovascular mechanical thrombectomy therapy (MT) are well established in the treatment of acute ischemic stroke. It is currently unclear whether these treatments can be applied in patients with previous deep brain stimulation (DBS) surgery and how long the interval to the DBS operation should be.

Methods: Four patients with ischemic stroke and IVT or MT were included in this retrospective case series. Data on demographics, genesis, severity and course of the stroke and the DBS indication were extracted and evaluated. Furthermore, a literature review was conducted. Outcomes and hemorrhagic complications after IVT, MT or intra-arterial thrombolysis in patients with prior deep brain stimulation surgery and intracranial surgery were analyzed.

Results: Four patients with acute ischaemic stroke and previous DBS surgery were treated with IVT (2 patients), MT (1) or a combined therapy of IVT and MT (1). The time interval to the previous DBS surgery was between 6 and 135 months. In these four patients, no bleeding complications occurred. The literature review revealed four publications with a total of 18 patients, who were treated with IVT, MT or intra-arterial thrombolysis. Of these 18 patients, only 1 had undergone deep brain stimulation surgery, the other 17 patients had received brain surgery for other reasons. Bleeding complications occurred in four of the 18 reported patients, but not in the DBS case. All four patients with bleeding complications were reported to have died as a result. In three of the four patients with fatal outcome, surgery was less than 90 days before the onset of stroke.

Conclusion: IVT and MT were tolerated by four patients with ischemic stroke more than 6 months after DBS surgery without bleeding complications.

Keywords: Deep brain stimulation; Endovascular mechanical recanalization therapy; Intravenous thrombolysis.

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Conflict of interest statement

Dr. Meyne reports no conflicts of interest. Dr. Domschikowski reports no conflicts of interest. Dr. Hensler reports no conflicts of interest. Dr. Helmers reports no conflicts of interest. Dr. Berg received consultancies/advisory board fees for Biogen, BIAL, UCB Pharma GmbH, Zambon, honoraria for talks/lectures from AbbVie, Bayser, Biogen, BIAL, UCB Pharma GmbH, Zambon, and Desitin and grants/research funding from Deutsche Forschungsgemeinschaft (DFG), German Parkinson’s Disease Association (dPV), BMBF, Parkinson Fonds Deutschland gGmbH, UCB Pharma GmbH, EU, Novartis Pharma GmbH, Lundbeck, and the Damp Foundation. Dr. Deuschl received fees for lecturing from Boston Scientific and consulting fees from Boston Scientific, Cavion, Functional modulation. He receives funding for his research to his institution from the German Research Council, SFB 1261, B5, and Medtronic. Dr. Paschen reports speaker honoraria from Insightec, AbbVie, Medtronic GmbH and Boston Scientific outside the submitted work and travel grants from Desitin and Abbvie and grant/research funding from Parkinson Fonds Deuschland gGmbH and UCB Pharma GmbH.

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