Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Dec 31;19(1):2213603.
doi: 10.1080/21645515.2023.2213603. Epub 2023 May 23.

Human papillomavirus vaccination at the first opportunity: An overview

Robert A Bednarczyk  1   2   3   4 , Noel T Brewer  5   6 , Melissa B Gilkey  5   6 , Sherri Zorn  7 , Rebecca B Perkins  8 , Kristin Oliver  9 , Debbie Saslow  10
Affiliations
Review

Human papillomavirus vaccination at the first opportunity: An overview

Robert A Bednarczyk et al. Hum Vaccin Immunother. .

Abstract

The Advisory Committee on Immunization Practices (ACIP) has recommended human papillomavirus (HPV) vaccination for adolescents in the United States since 2006. Though recommended at a similar time to the routine recommendations for adolescent tetanus, diphtheria, and acellular pertussis vaccination (Tdap) and quadrivalent meningococcal vaccination (MCV4), HPV vaccine uptake has consistently lagged behind these other adolescent vaccines. The ACIP recommends HPV vaccination at 11-12 y, with vaccination starting at 9 y of age included as an option that is routinely encouraged by the American Academy of Pediatrics and American Cancer Society. To support efforts to increase HPV vaccination at the first opportunity, this commentary summarizes the current HPV vaccination recommendations and available evidence regarding HPV vaccination starting at 9 y - including recent studies and trials documenting the effectiveness of HPV vaccination at 9 in supporting vaccine series completion, while providing future directions for research and implementation to improve HPV vaccination.

Keywords: HPV; HPV vaccination; Human papillomavirus; adolescent; vaccination recommendations.

PubMed Disclaimer

Conflict of interest statement

Drs. Bednarczyk, Gilkey, Zorn, Perkins, Oliver, and Saslow have no conflicts of interest to report. Dr Brewer has served as a paid consultant for Merck and Sanofi.

References

    1. Bilukha OO, Rosenstein N.. Prevention and control of meningococcal disease. Recommendations of the advisory committee on immunization practices (ACIP). MMWR Recomm Rep. 2005. May 27;54(Rr–7):1–5. - PubMed
    1. Broder KR, Cortese MM, Iskander JK, Kretsinger K, Slade BA, Brown KH, Mijalski CM, Tiwari T, Weston EJ, Cohn AC, et al. Preventing tetanus, diphtheria, and pertussis among adolescents: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccines recommendations of the advisory committee on immunization practices (ACIP). MMWR Recomm Rep. 2006. Mar 24;55(Rr–3):1–34. - PubMed
    1. Markowitz LE, Dunne EF, Saraiya M, Lawson HW, Chesson H, Unger ER.. Quadrivalent human papillomavirus vaccine: recommendations of the advisory committee on immunization practices (ACIP). MMWR Recomm Rep. 2007. Mar 23;56(Rr–2):1–24. - PubMed
    1. Committee on Infectious Diseases . Recommended immunization schedules for children and adolescents–United States, 2007. Pediatrics. 2007. Jan;119(1):207–8. doi:10.1542/peds.2006-3309. - DOI - PubMed
    1. Saslow D, Castle PE, Cox JT, Davey DD, Einstein MH, Ferris DG, Goldie SJ, Harper DM, Kinney W, Moscicki A-B, et al. American cancer society guideline for human papillomavirus (HPV) vaccine use to prevent cervical cancer and its precursors. CA Cancer J Clin. 2007. Jan-Feb;57(1):7–28. doi:10.3322/canjclin.57.1.7. - DOI - PubMed

Publication types

Substances