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Review
. 2023 Aug;45(8):1934-1942.
doi: 10.1002/hed.27417. Epub 2023 May 23.

Head and neck solitary fibrous tumors: A review of the National Cancer Database

Arash Abiri  1 , Cecilia Nguyen  1 , Kareem Latif  1 , Khodayar Goshtasbi  1 , Sina J Torabi  1 , Jack L Birkenbeuel  1 , Edward C Kuan  1
Affiliations
Review

Head and neck solitary fibrous tumors: A review of the National Cancer Database

Arash Abiri et al. Head Neck. 2023 Aug.

Abstract

Background: Head and neck solitary fibrous tumors (SFTs) are rare neoplasms, with few large-scale studies describing this entity. We evaluated the demographics and correlates of survival in a large series of SFT patients.

Methods: The 2004-2017 National Cancer Database was queried for head and neck SFT patients receiving definitive surgery. Cox proportional-hazards and Kaplan-Meier analyses assessed overall survival (OS).

Results: Of 135 patients, sinonasal (33.1%) and orbital (25.9%) SFTs were most common. Approximately 93% of SFTs were invasive and 64% were classified as hemangiopericytomas. The 5-year OS of skull base SFTs (84.5%) was lower than sinonasal (98.7%) and orbital (90.7%) SFTs (all p < 0.05). Government insurance exhibited higher mortality (HR 5.116; p < 0.001) and lower OS (p = 0.001).

Conclusion: Head and neck SFTs presented with distinct prognoses based on anatomical origin. Overall survival was particularly worse in patients with skull base SFTs or government insurance. Prognostically, hemangiopericytomas were indistinct from other SFTs.

Keywords: demographics; head and neck; hemangiopericytoma; prognosis; solitary fibrous tumor; survival.

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