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Review
. 2023 Nov;26(11):2304-2309.
doi: 10.1111/1756-185X.14740. Epub 2023 May 23.

Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome with cranial bone involvement: Case report and literature review

Yuan Li  1 , Xiujuan Hou  2 , Shengyan Liu  3 , Siyi Lu  1 , Mengmeng Du  1 , Xia Dong  4 , Xiaoping Liu  2 , Chen Li  4
Affiliations
Review

Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome with cranial bone involvement: Case report and literature review

Yuan Li et al. Int J Rheum Dis. 2023 Nov.

Abstract

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoimmune inflammatory disease characterized by osteoarticular and dermatological manifestations. The most common osteoarticular manifestations involve the anterior chest wall, axial skeleton, and long bones. Cranial bone involvement is less reported in SAPHO syndrome. We herein present three cases of SAPHO syndrome with cranial bone involvement, and review the previous literature on similar manifestations. It was revealed that SAPHO syndrome could lead to cranial bone involvement, which could involve the dura mater, leading to hypertrophic pachymeningitis, but the outcome is usually good. Janus kinase inhibitors may be a potential treatment option.

Keywords: Janus kinase inhibitors; SAPHO syndrome synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome; cranial bone; palmoplantar pustulosis.

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References

REFERENCES

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