Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jan-Dec:19:17455057231176655.
doi: 10.1177/17455057231176655.

An overview of the management of osteoporosis in the aging female population

Usman Amin  1 , Aoife McPartland  1 , Miriam O'Sullivan  1 , Carmel Silke  1   2
Affiliations
Review

An overview of the management of osteoporosis in the aging female population

Usman Amin et al. Womens Health (Lond). 2023 Jan-Dec.

Abstract

Osteoporosis is a systemic skeletal disease that is a cause of morbidity and mortality. It can affect all ages but most frequently postmenopausal women. It is a silent condition, however, osteoporotic fractures can lead to significant pain and disability. In this review article, we aim to review the clinical approach to the management of postmenopausal osteoporosis. We include risk assessment, investigations, and the various pharmacological and non-pharmacological options used in the treatment of osteoporosis. We have discussed the pharmacological options individually including their mechanism of action, safety profile, effects on bone mineral density and fracture risks, and duration of use. Potential new treatments are also discussed. The importance of sequence in the use of osteoporotic medicine is also highlighted in the article. An understanding of the different treatment options will hopefully help in the management of this very common and debilitating condition.

Keywords: antiresorptive agents; bisphosphonates; bone health; denosumab; fracture risk; osteoporosis; postmenopausal; teriparatide.

PubMed Disclaimer

Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Digital Science & Research Solutions, Inc. Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 1993; 94(6): 646–650. - PubMed
    1. Harvey N, Dennison E, Cooper C. Osteoporosis: impact on health and economics. Nat Rev Rheumatol 2010; 6(2): 99–105. - PubMed
    1. Kanis JA, Johnell O, Oden A, et al.. Risk of hip fracture according to the World Health Organization criteria for osteopenia and osteoporosis. Bone 2000; 27(5): 585–590. - PubMed
    1. Sözen T, Özışık L, Başaran NÇ. An overview and management of osteoporosis. Eur J Rheumatol 2017; 4(1): 46–56. - PMC - PubMed
    1. Leibson CL, Tosteson ANA, Gabriel SE, et al.. Mortality, disability, and nursing home use for persons with and without hip fracture: a population-based study. J Am Geriatr Soc 2002; 50(10): 1644–1650. - PubMed

MeSH terms