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Review
. 2023 Sep;23(9):e202300114.
doi: 10.1002/tcr.202300114. Epub 2023 May 23.

The Revival of Enantioselective Perfluoroalkylation - Update of New Synthetic Approaches from 2015-2022

Marina Briand  1 , Elsa Anselmi  1   2 , Guillaume Dagousset  1 , Emmanuel Magnier  1
Affiliations
Review

The Revival of Enantioselective Perfluoroalkylation - Update of New Synthetic Approaches from 2015-2022

Marina Briand et al. Chem Rec. 2023 Sep.

Abstract

Over the last years, methods devoted to the synthesis of asymmetric molecules bearing a perfluoroalkylated chain have been limited in number. Among them, only a few can be used on a large variety of scaffolds. This microreview aims at summarizing these recent advances in enantioselective perfluoroalkylation (-CF3 , -CF2 H, -Cn F2n+1 ) and highlights the need for new enantioselective methods to easily synthesize chiral fluorinated molecules which would be useful for the pharmaceutical and agrochemical industries. Some perspectives are also mentioned.

Keywords: Asymmetric catalysis; Enantioselectivity; Fluorine; Perfluoroalkyl chains.

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