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Review
. 2023 May 17:16:2149-2157.
doi: 10.2147/JIR.S413179. eCollection 2023.

Research Progress of Hydrogen on Chronic Nasal Inflammation

Ling Jin #  1   2 , Shiwang Tan #  1 , Kai Fan #  1 , Yang Wang  1 , Shaoqing Yu  1   2
Affiliations
Review

Research Progress of Hydrogen on Chronic Nasal Inflammation

Ling Jin et al. J Inflamm Res. .

Abstract

Chronic nasal mucosal inflammatory disease is a common nasal disease, which is involved by inflammatory cells and a variety of cytokines. Its main pathological features are inflammatory reaction, increased secretion, mucosal swelling and thickening of nasal cavity or paranasal sinuses.It mainly includes chronic rhinitis (divided into allergic rhinitis, non-allergic rhinitis), chronic sinusitis (divided into with nasal polyps, without nasal polyps type), etc.The main symptoms of chronic rhinitis are nasal itching, sneezing, runny nose, and nasal congestion. The main symptoms of chronic sinusitis are nasal congestion, purulent or sticky nasal discharge, headache, and reduced sense of smell. They are a type of disease with a high incidence rate and seriously affect the quality of human life.Although the etiology and treatment of this type of disease have been extensively studied, there are still many aspects that are unclear.Currently, oxidative stress is believed to be an important link in the pathogenesis of chronic inflammatory diseases of the nasal mucosa. Therefore, anti-oxidative stress is a direction of research for the treatment of chronic nasal mucosal inflammatory diseases.Hydrogen, as a medically therapeutic gas, has been extensively studied for its antioxidant, anti-inflammatory, and anti-damage properties, and has been used in the treatment of various diseases.Although there are relatively few studies on the use of hydrogen for nasal inflammation, its positive effects have also been found. This article systematically summarizes the relevant research on the use of hydrogen to improve chronic nasal mucosal inflammation, with the aim of clarifying the ideas and indicating the direction for further research in the future.

Keywords: allergic rhinitis; chronic rhinitis; chronic sinusitis; hydrogen; non-allergic rhinitis; research progress.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Oxidative stress machine in nasal mucosal inflammation.
Figure 2
Figure 2
Mechanism of hydrogen on nasal mucosal inflammation.
See this image and copyright information in PMC

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