Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 May 23;16(5):e253484.
doi: 10.1136/bcr-2022-253484.

Giant cell arteritis presenting with unilateral sixth nerve palsy

Affiliations
Case Reports

Giant cell arteritis presenting with unilateral sixth nerve palsy

Matthew Colquhoun et al. BMJ Case Rep. .

Abstract

Giant cell arteritis (GCA) usually presents with headache, scalp tenderness and raised inflammatory markers. GCA presenting with a clinically evident cranial nerve palsy is rare and may result in a delayed or missed diagnosis if not suspected. We present the rare case of a woman in her 70s with histologically confirmed GCA presenting with a unilateral sixth nerve palsy, which responded to treatment with high-dose oral prednisolone.

Keywords: Cranial nerves; Vasculitis.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Temporal artery biopsy (A, B): while no giant cells are seen, there is florid lymphohistiocytic inflammation in this temporal artery, it is mainly in the adventitia, but focally penetrates into the media and reaches the level of the internal elastic lamina, which shows extensive damage on elastic Van Gieson’s (EVG) stain.

Similar articles

Cited by

References

    1. Dasgupta B, Frances A B, Hassan N, et al. . BSR and BHPR standards, guidelines and audit working group, BSR and BHPR guidelines for the management of giant cell arteritis. Rheumatology 2010;49:1594–7. 10.1093/rheumatology/keq039a - DOI - PubMed
    1. Lie JT. Illustrated histopathologic classification criteria for selected vasculitis syndromes. Arthritis & Rheumatism 1990;33:1074–87. 10.1002/art.1780330804 - DOI - PubMed
    1. Hernández-Rodríguez J, Murgia G, Villar I, et al. . Description and validation of histological patterns and proposal of a dynamic model of inflammatory infiltration in giant-cell arteritis. Medicine (Baltimore) 2016;95. 10.1097/MD.0000000000002368 - DOI - PMC - PubMed
    1. Wang AL, Raven ML, Surapaneni K, et al. . Studies on the Histopathology of temporal arteritis. Ocul Oncol Pathol 2017;3:60–5. 10.1159/000449466 - DOI - PMC - PubMed
    1. Margolin EM, Jeeva-Patel TMD. Sixth nerve palsy and myocarditis as the only presenting manifestation of giant cell arteritis. J Neuroophthalmol 2021;41:e335–6. 10.1097/WNO.0000000000001054 - DOI - PubMed

Publication types