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Comment
. 2023 Oct;33(10):739-740.
doi: 10.1038/s41422-023-00828-w.

CAR T cell design: approaching the elusive AND-gate

Zeguo Zhao  1 , Michel Sadelain  2
Affiliations
Comment

CAR T cell design: approaching the elusive AND-gate

Zeguo Zhao et al. Cell Res. 2023 Oct.
No abstract available

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Figures

Fig. 1
Fig. 1. Principles of logic-gated CAR T cells, schematic depiction of LINK CARs and antigen density impact on logic-gates.
a OR, NOT, AND, and IF-BETTER gates. b LINK CAR platforms. c Where AND, OR and IF-BETTER gates meet. Left column: AND-gated CAR T cells (LINK) only engage A+B+ target cells; OR-gated CAR T cells engage A+B–, A–B+ and A+B+ target cells; IF-BETTER-gated CAR T cells (CARA + CCRB) engage A+ target cells. Middle and right columns: the OR-gate and IF-BETTER-gate act as AND-gate when A is of insufficient density (Alow) to alone activate its cognate receptor, depending on the density of B.
See this image and copyright information in PMC

Comment on

  • Co-opting signalling molecules enables logic-gated control of CAR T cells.
    Tousley AM, Rotiroti MC, Labanieh L, Rysavy LW, Kim WJ, Lareau C, Sotillo E, Weber EW, Rietberg SP, Dalton GN, Yin Y, Klysz D, Xu P, de la Serna EL, Dunn AR, Satpathy AT, Mackall CL, Majzner RG. Tousley AM, et al. Nature. 2023 Mar;615(7952):507-516. doi: 10.1038/s41586-023-05778-2. Epub 2023 Mar 8. Nature. 2023. PMID: 36890224 Free PMC article.

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Substances

LinkOut - more resources