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. 2023 Aug 1;33(4):275-282.
doi: 10.1097/CMR.0000000000000899. Epub 2023 May 23.

Chemical features of melanoma tumor resident TRG CDR3s associated with better survival probabilities

Deo Rei L Agnila  1 , Taha I Huda  1 , Rachel A Eakins  1 , Dhruv N Patel  1 , Monica Hsiang  1 , Andrea Chobrutskiy  2 , Boris I Chobrutskiy  3 , George Blanck  1   4
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Chemical features of melanoma tumor resident TRG CDR3s associated with better survival probabilities

Deo Rei L Agnila et al. Melanoma Res. .

Abstract

We assessed the T-cell receptor gamma (TRG) recombination reads from the cancer genome atlas melanoma tumor exome files and the TRG recombination reads from an independent, melanoma exome file dataset, from the Moffitt Cancer Center. TRG complementarity determining region-3 (CDR3) amino acid (AA) sequences were assessed for chemical complementarity to cancer testis antigens, with such complementarity for FAM133A and CRISP2 associated with better survival probabilities for both datasets. These results, along with related TRG CDR3 AA chemical feature assessments provided in this report, have indicated opportunities for melanoma patient stratifications based on the recovery of TRG recombination reads from both tumor and blood samples, and the results may point towards novel, effective melanoma antigens.

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