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Review
. 2023 Jul 1;35(4):301-308.
doi: 10.1097/CCO.0000000000000954. Epub 2023 May 9.

Next questions in the management of retroperitoneal sarcoma

Ashley Drohan  1 , Alessandro Gronchi  2
Affiliations
Review

Next questions in the management of retroperitoneal sarcoma

Ashley Drohan et al. Curr Opin Oncol. .

Abstract

Purpose of review: Retroperitoneal soft-tissue sarcomas (RPS) are a group of rare, histologically distinct tumours with variable recurrence patterns depending on histological type. This review will discuss the growing body of evidence supporting histology-specific, multidisciplinary management and highlight areas of future research for patients with RPS.

Recent findings: Histology-tailored surgery is the cornerstone of management in patients with localized RPS. Further efforts to develop resectability criteria and identify patients who will benefit from neoadjuvant treatment strategies will help standardize the treatment of patients with localized RPS. Surgery for local recurrence is well tolerated in selected patients and re-iterative surgery in liposarcoma (LPS) may be beneficial at the time of local recurrence. The management of advanced RPS holds promise with several trials currently investigating systemic treatment beyond conventional chemotherapy.

Summary: The management of RPS has made significant progress over the past decade owing to international collaboration. Ongoing efforts to identify patients who will derive the most benefit from all treatment strategies will continue to advance the field of RPS.

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References

    1. Blay J, Honoré C, Stoeckle E, et al. Surgery in reference centers improves survival of sarcoma patients: a nationwide study. Ann Oncol 2019; 30:1143–1153.
    1. de Pinieux G, Karanian M, Le Loarer F, et al. Nationwide incidence of sarcomas and connective tissue tumors of intermediate malignancy over four years using an expert pathology review network. PLoS One 2021; 16:e0246958.
    1. Tan MC, Brennan M, Kuk D, et al. Histology-based classification predicts pattern of recurrence and improves risk stratification in primary retroperitoneal sarcoma. Ann Surg 2016; 263:593–600.
    1. Gronchi A, Strauss D, Miceli R, et al. Variability in patterns of recurrence after resection of primary retroperitoneal sarcoma (RPS): a report on 1007 patients from the multiinstitutional collaborative RPS working group. Ann Surg 2016; 263:1002–1009.
    1. van Houdt WJ, Zaidi S, Messiou C, et al. Treatment of retroperitoneal sarcoma: current standards and new developments. Curr Opin Oncol 2017; 29:260–267.

MeSH terms