Comparative Study on Phenolic Profile and Biological Activities of the Aerial Parts of Sinapis pubescens L. subsp. pubescens (Brassicaceae) Wild from Sicily (Italy)

Paola Arena^{1

2}, Natalizia Miceli¹, Andreana Marino¹, Federica Davì^{1

2}, Emilia Cavò^{1

2}, Vivienne Spadaro³, Francesco Maria Raimondo⁴, Francesco Cacciola⁵, Roberto Laganà Vinci¹, Luigi Mondello^{1

6

7}, Maria Fernanda Taviano¹

Affiliations

¹ Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166, Messina, Italy.
² Foundation "Prof. Antonio Imbesi", University of Messina, Piazza Pugliatti 1, 98122, Messina, Italy.
³ Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, Section of Botany, Anthropology and Zoology, University of Palermo, Via Archirafi 38, 90123, Palermo, Italy.
⁴ PLANTA/Research, Documentation and Training Center, Via Serraglio Vecchio 28, 90123, Palermo, Italy.
⁵ Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
⁶ Chromaleont s.r.l., c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Palatucci, 98168, Messina, Italy.
⁷ Department of Sciences and Technologies for Human and Environment, University Campus Bio-Medico of Rome, via Àlvaro del Portillo 21, 00128, Rome, Italy.

PMID: 37222439
DOI: 10.1002/cbdv.202300309

Comparative Study on Phenolic Profile and Biological Activities of the Aerial Parts of Sinapis pubescens L. subsp. pubescens (Brassicaceae) Wild from Sicily (Italy)

Paola Arena et al. Chem Biodivers. 2023 Jun.

. 2023 Jun;20(6):e202300309.

doi: 10.1002/cbdv.202300309. Epub 2023 Jun 6.

Authors

Affiliations

¹ Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166, Messina, Italy.
² Foundation "Prof. Antonio Imbesi", University of Messina, Piazza Pugliatti 1, 98122, Messina, Italy.
³ Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, Section of Botany, Anthropology and Zoology, University of Palermo, Via Archirafi 38, 90123, Palermo, Italy.
⁴ PLANTA/Research, Documentation and Training Center, Via Serraglio Vecchio 28, 90123, Palermo, Italy.
⁵ Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Via Consolare Valeria, 98125, Messina, Italy.
⁶ Chromaleont s.r.l., c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Palatucci, 98168, Messina, Italy.
⁷ Department of Sciences and Technologies for Human and Environment, University Campus Bio-Medico of Rome, via Àlvaro del Portillo 21, 00128, Rome, Italy.

PMID: 37222439
DOI: 10.1002/cbdv.202300309

Abstract

This work aimed to investigate Sinapis pubescens subsp. pubescens spontaneously grown in Sicily (Italy) as new potential source of active metabolites; specifically, a comparative study on leaf, flower, and stem hydroalcoholic extracts was performed. Polyphenols were quantitatively determined by spectrophotometric methods and characterized by HPLC-PDA/ESI-MS; a total of 55 polyphenolic compounds were identified, highlighting considerably different qualitative-quantitative profiles. The extracts showed antioxidant activity, evaluated by in vitro assays; particularly, the leaf extract displayed the best radical scavenging activity (DPPH test) and reducing power, while the flower extract showed the greatest chelating activity. The antimicrobial properties of the extracts were investigated against bacteria and yeasts by standard methods; no antimicrobial activity was found against the strains tested. The extracts resulted to be non-toxic after preliminary toxicity evaluation by the Artemia salina lethality bioassay. The aerial parts of S. pubescens subsp. pubescens proved to be valuable sources of antioxidants for pharmaceutical and nutraceutical applications.

Keywords: antimicrobial activity; antioxidants; phytochemistry; sicilian vascular flora; toxicity assessment.

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References

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1. K. Kubitzki, C. Bayer, ‘Flowering plants. Dicotyledons - Malvales, Capparales and non-betalain Caryophyllales’, Springer, Berlin Heidelberg, 2003, p. 159.
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1. T. G. Tutin, V. H. Heywood, N. A. Burges, D. M. Moore, D. H. Valentine, S. M. Walters, D. A. Webb, ‘Flora Europea’, Cambridge University Press, Cambridge,1964, Vol. 1, p. 339.

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Comparative Study on Phenolic Profile and Biological Activities of the Aerial Parts of Sinapis pubescens L. subsp. pubescens (Brassicaceae) Wild from Sicily (Italy)

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Comparative Study on Phenolic Profile and Biological Activities of the Aerial Parts of Sinapis pubescens L. subsp. pubescens (Brassicaceae) Wild from Sicily (Italy)

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