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Review
. 2023 Dec;29(12):1142-1146.
doi: 10.1007/s11655-023-3631-2. Epub 2023 May 24.

Therapeutic Effects of Shenfu Injection in Shock

Affiliations
Review

Therapeutic Effects of Shenfu Injection in Shock

Ming-Qing Zhang et al. Chin J Integr Med. 2023 Dec.

Abstract

Shock is the clinical manifestation of acute circulatory failure, which results in inadequate utilization of cellular oxygen. It is a common condition with high mortality rates in intensive care units. The intravenous administration of Shenfu Injection (SFI) may attenuate inflammation, regulate hemodynamics and oxygen metabolism; inhibit ischemia-reperfusion responses; and have adaptogenic and antiapoptotic effects. In this review, we have discussed the clinical applications and antishock pharmacological effects of SFI. Further in-depth and large-scale multicenter clinical studies are warranted to determine the therapeutic effects of SFI on shock.

Keywords: Chinese medicine; Shenfu Injection; pathophysiology; shock.

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References

    1. Cecconi M, De Backer D, Antonelli M, Beale R, Bakker J, Hofer C, et al. Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med 2014;40:1795–1815. - PubMed - PMC - DOI
    1. Bortolotti P, Faure E, Kipnis E. Inflammasomes in tissue damages and immune disorders after trauma. Front Immunol 2018;9:1900. - PubMed - PMC - DOI
    1. Guven G, Hilty MP, Ince C. Microcirculation: physiology, pathophysiology, and clinical application. Blood Purif 2020;49:143–150. - PubMed - DOI
    1. Massey MJ, Hou PC, Filbin M, Wang H, Ngo L, Huang DT, et al. Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial. Crit Care 2018;22:308. - PubMed - PMC - DOI
    1. Wijntjens GW, Fengler K, Fuernau G, Jung C, den Uil C, Akin S, et al. Prognostic implications of microcirculatory perfusion versus macrocirculatory perfusion in cardiogenic shock: a CULPRIT-SHOCK substudy. Eur Heart J Acute Cardiovasc Care 2020;9:108–119. - PubMed - DOI

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