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. 2023 May 8:14:1149473.
doi: 10.3389/fendo.2023.1149473. eCollection 2023.

Genes in loci genetically associated with polycystic ovary syndrome are dynamically expressed in human fetal gonadal, metabolic and brain tissues

Rafiatu Azumah  1 , Katja Hummitzsch  1 , Richard A Anderson  2 , Raymond J Rodgers  1
Affiliations

Genes in loci genetically associated with polycystic ovary syndrome are dynamically expressed in human fetal gonadal, metabolic and brain tissues

Rafiatu Azumah et al. Front Endocrinol (Lausanne). .

Abstract

Background: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder, affecting around 10% of women of reproductive age, with infertility, depression or anxiety, obesity, insulin resistance and type 2 diabetes as risk factors. The cause of PCOS is not known but there is a predisposition to developing PCOS in adult life that arises during fetal or perinatal life. PCOS also has a genetic predisposition and a number of genetic loci associated with PCOS have been identified. These loci contain 25 candidate genes which are currently being studied to define the syndrome. Although the name PCOS suggests a syndrome of the ovary, PCOS has also been associated with the central nervous system and other organ systems in the body due to the wide variety of symptoms it presents.

Methods: Here, we examined the expression patterns of PCOS candidate genes in gonadal (ovary and testis), metabolic (heart, liver and kidney) and brain (brain and cerebellum) tissues during the first half of human fetal development and postnatally until adulthood using public RNA sequencing data. This study is an initial step for more comprehensive and translational studies to define PCOS.

Results: We found that the genes were dynamically expressed in the fetal tissues studied. Some genes were significantly expressed in gonadal tissues, whilst others were expressed in metabolic or brain tissues at different time points prenatally and/or postnatally. HMGA2, FBN3 and TOX3 were highly expressed during the early stages of fetal development in all tissues but least during adulthood. Interestingly, correlation between expression of HMGA2/YAP1 and RAD50/YAP1 were significant in at least 5 of the 7 fetal tissues studied. Notably, DENND1A, THADA, MAPRE1, RAB5B, ARL14EP, KRR1, NEIL2 and RAD50 were dynamically expressed in all postnatal tissues studied.

Conclusions: These findings suggest that these genes have tissue- or development-specific roles in multiple organs, possibly resulting in the various symptoms associated with PCOS. Thus the fetal origin of a predisposition to PCOS in adulthood could arise via the effects of PCOS candidate genes in the development of multiple organs.

Keywords: PCOS (polycystic ovarian syndrome); brain; fetus; heart; kidney; liver; ovary; testis.

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Conflict of interest statement

RAA reports consultancy work for Ferring Merck, IBSA, Roche Diagnostics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Expression of HMGA2 in gonadal (A), metabolic (B) and brain tissues (C) during the first half of fetal development and postnatally. Short dashes distinguish fetal samples from postnatal ones.
Figure 2
Figure 2
Expression of YAP1 in gonadal (A), metabolic (B) and brain tissues (C) during the first half of fetal development and during lifetime. Short dashes distinguish fetal samples from postnatal ones.
Figure 3
Figure 3
Expression of RAD50 in gonadal (A), metabolic (B) and brain tissues (C) during the first half of fetal development and during lifetime. Short dashes distinguish fetal samples from postnatal ones.
See this image and copyright information in PMC

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References

    1. Joham AE, Teede HJ, Ranasinha S, Zoungas S, Boyle J. Prevalence of infertility and use of fertility treatment in women with polycystic ovary syndrome: data from a large community-based cohort study. J Women's Health (2015) 24:299–307. doi: 10.1089/jwh.2014.5000 - DOI - PubMed
    1. Hart R, Doherty DA, Mori T, Huang R-C, Norman RJ, Franks S, et al. . Extent of metabolic risk in adolescent girls with features of polycystic ovary syndrome. Fertil Steril (2011) 95:2347–53.e1. doi: 10.1016/j.fertnstert.2011.03.001 - DOI - PubMed
    1. Teede H, Deeks A, Moran L. Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med (2010) 8:41. doi: 10.1186/1741-7015-8-41 - DOI - PMC - PubMed
    1. Hart R, Hickey M, Franks S. Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome. Best Pract Res Clin Obstetr Gynaecol (2004) 18:671–83. doi: 10.1016/j.bpobgyn.2004.05.001 - DOI - PubMed
    1. Anagnostis P, Tarlatzis BC, Kauffman RP. Polycystic ovarian syndrome (PCOS): long-term metabolic consequences. Metabolism (2018) 86:33–43. doi: 10.1016/j.metabol.2017.09.016 - DOI - PubMed

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