Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 May 18:15:765-778.
doi: 10.2147/IJWH.S351095. eCollection 2023.

Prevalence, Impact, and Diagnostic Challenges of Benign Breast Disease: A Narrative Review

Jessica L Fraker  1 , Caroline G Clune #  2   3 , Sabrina K Sahni #  4 , Avani Yaganti #  5 , Suneela Vegunta  1
Affiliations
Review

Prevalence, Impact, and Diagnostic Challenges of Benign Breast Disease: A Narrative Review

Jessica L Fraker et al. Int J Womens Health. .

Abstract

Benign breast diseases, which are commonly seen in clinical practice, have various clinical presentations and implications, as well as management strategies. This article describes common benign breast lesions, presentations of these lesions, and typical radiographic and histologic findings. Also included in this review are the most recent data and guideline-based recommendations for the management of benign breast diseases at diagnosis, including surgical referral, medical management, and ongoing surveillance.

Keywords: breast biopsy; imaging; management; surveillance.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Sonographic image showing a fibroepithelial lesion with borderline findings. Biopsy revealed phyllodes tumor.
Figure 2
Figure 2
Sonographic image showing multiple papillomas.
Figure 3
Figure 3
Sonographic image showing a single papilloma with cystic spaces.
Figure 4
Figure 4
Magnetic resonance image showing enhancement in the area of pseudoangiomatous stromal hyperplasia.
Figure 5
Figure 5
Mammographic image showing distortion in an area of radial scar. Yellow circle on figure outlines area of architectural distortion on mammography, biopsy revealed radial scar on pathology.
Figure 6
Figure 6
Mammographic image showing calcifications. Biopsy revealed flat epithelial atypia and atypical ductal hyperplasia. Yellow and white circles on figure outline areas of calcifications on mammography, biopsies revealed flat epithelial atypia and atypical ductal hyperplasia.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Klassen CL, Hines SL, Ghosh K. Common benign breast concerns for the primary care physician. Cleve Clin J Med. 2019;86(1):57–65. doi:10.3949/ccjm.86a.17100 - DOI - PubMed
    1. Hartmann LC, Sellers TA, Frost MH, et al. Benign breast disease and the risk of breast cancer. N Engl J Med. 2005;353(3):229–237. doi:10.1056/NEJMoa044383 - DOI - PubMed
    1. Wu Y-T, Chen S-T, Chen C-J, et al. Breast cancer arising within fibroadenoma: collective analysis of case reports in the literature and hints on treatment policy. World J Surg Oncol. 2014;12(1):335. doi:10.1186/1477-7819-12-335 - DOI - PMC - PubMed
    1. Kulka J, Madaras L, Floris G, Lax SF. Papillary lesions of the breast. Virchows Arch. 2022;480(1):65–84. doi:10.1007/s00428-021-03182-7 - DOI - PMC - PubMed
    1. Jatana S, Zahra S, Miron AD, et al. A retrospective study evaluating outcomes of surgical excision versus radiologic follow-up of benign breast papillomas without atypia. Am J Surg. 2022;224(3):932–937. doi:10.1016/j.amjsurg.2022.04.029 - DOI - PubMed