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Case Reports
. 2023 May 8:14:1132692.
doi: 10.3389/fimmu.2023.1132692. eCollection 2023.

Case Report: ICIs-induced Guillain-Barré syndrome recovered from mycophenolate mofetil

Mengge Ding  1 , Chao Deng  1 , Xianling Liu  1 , Shun Jiang  1 , Yuan Gao  2 , Dan Fan  1 , Yiguang Zhou  1 , Jiangbo He  1 , Chaoyuan Liu  1
Affiliations
Case Reports

Case Report: ICIs-induced Guillain-Barré syndrome recovered from mycophenolate mofetil

Mengge Ding et al. Front Immunol. .

Abstract

The emergence of immune checkpoint inhibitors (ICIs) has significantly prolonged the survival time of cancer patients. However, it may also lead to various immune-related adverse events (irAEs), including Guillain-Barré syndrome (GBS), a rare type of irAE. Most GBS patients can recover spontaneously due to the self-limited nature of the disease, but severe cases can result in respiratory failure or even death. Here we report a rare case of GBS occurring in a 58-year-old male patient with non-small cell lung cancer (NSCLC) who developed muscle weakness and numbness of the extremities during chemotherapy combined with KN046, a PD-L1/CTLA-4 bispecific antibody. Despite receiving methylprednisolone and γ-globulin, the patient's symptoms did not improve. However, there was significant improvement after treatment with mycophenolate mofetil (MM) capsules, which is not a routine regimen for GBS. To the best of our knowledge, this is the first reported case of ICIs-induced GBS that responded well to mycophenolate mofetil instead of methylprednisolone or γ-globulin. Thus, it provides a new treatment option for patients with ICIs-induced GBS.

Keywords: Guillain–Barré syndrome; KN046; immune checkpoint inhibitors; immune-related adverse events; mycophenolate mofetil.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The treatment procedure of the patient. (A) Methylprednisolone, (B) IVIG, (C) Mycophenolate mofetil capsules; *ivgtt, #po. ① Day of admission. ② Day of discharged.
See this image and copyright information in PMC

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