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. 2022 Apr 1;10(2):329-331.
doi: 10.1016/j.gendis.2022.02.020. eCollection 2023 Mar.

Loss of the emei tumor suppressor promotes tumorigenesis via the JNK and Hippo pathway

Shuai Yang  1   2   3 , Yifan Guo  1   2   3 , Xianjue Ma  1   2   3
Affiliations

Loss of the emei tumor suppressor promotes tumorigenesis via the JNK and Hippo pathway

Shuai Yang et al. Genes Dis. .
No abstract available

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Figures

Fig. 1
Figure 1
Emei regulates tumor progression via JNK and Hippo signaling. (A) Different genetic manipulations driven by ptc-Gal4 or en-Gal4. Wing discs were immunostained with anti-β-Gal antibody and DAPI. (B) Adult wings of the indicated genotypes using ptc-Gal4. (C) Different genetic manipulations driven by ptc-Gal4. Wing discs were immunostained with anti-Mmp1 antibody. (D, E) Eye discs containing GFP-marked MARCM clones of the indicted genotypes and were immunostained with anti-β-Gal antibody or anti-Egr antibody. (F, G) Different genetic manipulations driven by en-Gal4 or hh-Gal4. Wing discs were immunostained with anti-β-Gal antibody and DAPI. (H) Eye discs containing GFP-marked MARCM clones of the indicted genotypes and were immunostained with anti-Mmp1, anti-dMyc, or anti-Wg antibody. (I) Alteration frequency and oncoprint diagram of TMEM161B gene-alteration summary in patients with cancer (11,413) obtained from cBioPortal (The Cancer Genome Atlas, TGCA). (J) Pan-cancer transcription levels of TMEM161B gene in patients with cancer obtained from GEPIA 2. (K, L)TMEM161B expression is specially significantly lower in OV tumor samples compared to normal tissues and the lower levels of TMEM161B was existed in stage III and IV. (M) Low levels of TMEM161B expression correlated significantly with poor survival of patients. P values were determined by log-rank (Mante-Cox) test. (N) Proposed model of how Emei promotes tumorigenesis via the JNK and Hippo pathway.
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