Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Dec 16;10(2):430-446.
doi: 10.1016/j.gendis.2021.11.011. eCollection 2023 Mar.

Oncolytic viruses: A novel treatment strategy for breast cancer

Mohammad Javanbakht  1 , Sanaz Tahmasebzadeh  2 , Luca Cegolon  3   4 , Nasrin Gholami  5 , Mandana Kashaki  6 , Hassan Nikoueinejad  1 , Mohamad Mozafari  7 , Mahsa Mozaffari  8 , Shi Zhao  9 , Mostafa Khafaei  10 , Morteza Izadi  11 , Saeid Fathi  12 , Reza Akhavan-Sigari  13
Affiliations
Review

Oncolytic viruses: A novel treatment strategy for breast cancer

Mohammad Javanbakht et al. Genes Dis. .

Abstract

Breast cancer, an unceasingly occurring neoplasm, is one of the major determinants of mortality in women. Several ineffective attempts have been pursued using with conventional therapies against breast cancer. Resistance to existing therapies and their respective debilitating adverse effects have led research toward a new era of cancer treatment using viruses. Virotherapy constitutes a developing treatment modality with multiple mechanisms of therapeutic activity in which the viruses can be directly oncolyticand can express transgenes or induce host immune response against tumor cells. Several different DNA- and RNA-containing viruses have been considered for virotherapy of breast cancer including adenovirus, herpes virus, vaccinia, reovirus, Newcastle Disease virus, measles virus and vesicular stomatitis virus. This review aims to summarize the viro-therapeutical agents against breast malignancies. Key Scientific Concepts of Review: In this review paper, we proposed a new strategy to virus's combinatorial treatments using several kinds of transgenes and drugs. These recombinant viruses have provided evidence of treatment efficacy against human breast cancer.

Keywords: Adenovirus; Breast cancer; Herpes virus; Measles virus; Newcastle disease virus; Reovirus; Vaccinia; Vesicular stomatitis virus; Virotherapy.

PubMed Disclaimer

Conflict of interest statement

Authors declare no conflict of interests.

Figures

Fig. 1
Figure 1
Schematic view of cancer cell infection and lysis by oncolytic virus (OV).
Fig. 2
Figure 2
Schematic view of adenovirus.
Fig. 3
Figure 3
Schematic representation of adenovirus binding and internalization via CAR and αV integrins, respectively.
Fig. 4
Figure 4
Schematic view of T-VEC and oncolytic HSV-1 efficacy in tumor cell.
See this image and copyright information in PMC

References

    1. Sahin T.T., Kasuya H., Nomura N., et al. Impact of novel oncolytic virus HF10 on cellular components of the tumor microenviroment in patients with recurrent breast cancer. Cancer Gene Ther. 2012;19(4):229–237. - PubMed
    1. Cody J.J., Scaturro P., Cantor A.B., et al. Preclinical evaluation of oncolytic δγ(1)34.5Herpes simplex virus expressing interleukin-12 for therapy of breast cancer brain metastases. Int J Breast Cancer. 2012;2012:628697. - PMC - PubMed
    1. Li J., Zeng W., Huang Y., et al. Treatment of breast cancer stem cells with oncolytic Herpes simplex virus. Cancer Gene Ther. 2012;19(10):707–714. - PMC - PubMed
    1. Ranki T., Särkioja M., Hakkarainen T., et al. Systemic efficacy of oncolytic adenoviruses in imagable orthotopic models of hormone refractory metastatic breast cancer. Int J Cancer. 2007;121(1):165–174. - PubMed
    1. Bramante S., Koski A., Liikanen I., et al. Oncolytic virotherapy for treatment of breast cancer, including triple-negative breast cancer. Oncoimmunology. 2016;5(2) - PMC - PubMed

LinkOut - more resources