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. 2022 May 19;10(2):370-372.
doi: 10.1016/j.gendis.2022.05.005. eCollection 2023 Mar.

Circular RNA circEIF3C promotes intrahepatic cholangiocarcinoma progression and immune evasion via the miR-34a-5p/B7-H4 axis

Xiaoming Zhong  1 , Changxue Ji  2 , Dabin Ren  3 , Aiwu Ke  4 , Zhiwen Yang  5
Affiliations

Circular RNA circEIF3C promotes intrahepatic cholangiocarcinoma progression and immune evasion via the miR-34a-5p/B7-H4 axis

Xiaoming Zhong et al. Genes Dis. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Figure 1
Circular RNA circEIF3C promotes intrahepatic cholangiocarcinoma progression and immune evasion via the miR-34a-5p/B7–H4 axis. (A) Schematic illustration to display the circularization of EIF3Cexons 17–21 to form circEIF3C. (B) A diagram depicting how circEIF3C expression was determined in ICC samples from 50 patients. (C) Kaplan–Meier method was used to analyze the overall survival (OS) rate in 140 patients with ICC. (D) Results of circRIP exhibited a specific enrichment between circEIF3C and miR-34a-5p. (E) Representative images of B7–H4 and CD8 staining in serial TMA (Bar = 100 μm). (F) A diagram showing a positive correlation between circEIF3C and B7–H4 expression, and a negative correlation between CD8 and circEIF3C expression. (G) Work model: High circEIF3C expression promotes the progression of ICC by sponging miR-34a-5p, thereby increasing the translation of B7–H4.
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