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. 2023 May 12:32:668-670.
doi: 10.1016/j.omtn.2023.04.022. eCollection 2023 Jun 13.

Circulating ECVs prevent neurodegeneration and preserve neuronal function in a model of preclinical intracerebral hemorrhage

Annette Burkhart  1 , Torben Moos  1
Affiliations

Circulating ECVs prevent neurodegeneration and preserve neuronal function in a model of preclinical intracerebral hemorrhage

Annette Burkhart et al. Mol Ther Nucleic Acids. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Functional evaluation and brain imaging after treatment with extracellular vesicles in experimental hemorrhagic stroke (A) Functional evaluation tests along the study time points. “Δ” indicates p < 0.05 in AEV-treated animals compared with the control group. “O” indicates p < 0.05 in the XEVs-treated animals compared with the control group. The motor recovery of the animals treated with AEVs and XEVs was significantly better than that of the control group, as shown in all tests used in the study. (B) T2-MRI images. Colored lines mark the total volume of lesion at 48 h and the residual lesion at 28 days surrounded by dilated cisterns because of tissue retraction. The DTI-FA values were significantly higher in the treated animals compared with the controls at 28 days, indicating greater white matter integrity after either AEV or XEV treatment. ∗p < 0.05. Data are shown as mean ± SD. Abbreviations are as follows: AEVs, allogenic extracellular vesicles; FA, fractional anisotropy; ICH, intracerebral hemorrhage; XEVs, xenogeneic extracellular vesicles. Legends adapted and slightly modified from Laso-García et al.
See this image and copyright information in PMC

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