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. 2023:1417:141-157.
doi: 10.1007/978-981-99-1304-6_10.

Hepatitis E Virus Life Cycle

Xiaohui Ju  1 , Lin Dong  1 , Qiang Ding  2
Affiliations

Hepatitis E Virus Life Cycle

Xiaohui Ju et al. Adv Exp Med Biol. 2023.

Abstract

Hepatitis E virus (HEV) infects over 20 million people worldwide per year, leading to 30,000-40,000 deaths. In most cases HEV infection in a self-limited, acute illness. However, chronic infections could occur in immunocompromised individuals. Due to scarcity of robust cell culture models in vitro and genetic tractable animal models in vivo, the details of HEV life cycle, as well as its interaction with host cells still remain elusive, which dampens antivirals discovery. In this chapter, we present an update in the HEV infectious cycle steps: entry, genome replication/subgenomic RNA transcription, assembly, and release. Moreover, we discussed the future prospective on HEV research and illustrates important questions urgently to be addressed.

Keywords: Hepatitis E virus; Viral life cycle; Virus–host interactions.

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