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Review
. 2023 Aug 15;231(Pt 2):116222.
doi: 10.1016/j.envres.2023.116222. Epub 2023 May 22.

Endocrine-disrupting chemicals and autoimmune diseases

Rong-Gui Huang  1 , Xian-Bao Li  1 , Yi-Yu Wang  1 , Hong Wu  1 , Kai-Di Li  1 , Xue Jin  1 , Yu-Jie Du  1 , Hua Wang  1 , Fang-Yi Qian  2 , Bao-Zhu Li  3
Affiliations
Review

Endocrine-disrupting chemicals and autoimmune diseases

Rong-Gui Huang et al. Environ Res. .

Abstract

Endocrine-disrupting chemicals (EDCs) widely exist in people's production and life which have great potential to damage human and animal health. Over the past few decades, growing attention has been paid to the impact of EDCs on human health, as well as immune system. So far, researchers have proved that EDCs (such as bisphenol A (BPA), phthalate, tetrachlorodibenzodioxin (TCDD), etc.) affect human immune function and promotes the occurrence and development of autoimmune diseases (ADs). Therefore, in order to better understand how EDCs affect ADs, we summarized the current knowledge about the impact of EDCs on ADs, and elaborated the potential mechanism of the impact of EDCs on ADs in this review.

Keywords: Autoimmune diseases; Endocrine environmental disruptors; Inflammatory bowel disease; Rheumatoid arthritis; System lupus erythematosus; Type 1 diabetes.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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