Mitoprotease LONP1 controls white-to-beige adipocyte conversion via metabolic enzyme turnover

No authors listed

Comment

No authors listed. Nat Cell Biol. 2023 Jun.

. 2023 Jun;25(6):810-811.

doi: 10.1038/s41556-023-01161-5.

No abstract available

Comment on

Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes.
Fu T, Sun W, Xue J, Zhou Z, Wang W, Guo Q, Chen X, Zhou D, Xu Z, Liu L, Xiao L, Mao Y, Yang L, Yin Y, Zhang XN, Wan Q, Lu B, Chen Y, Zhu MS, Scherer PE, Fang L, Piao HL, Shao M, Gan Z. Fu T, et al. Nat Cell Biol. 2023 Jun;25(6):848-864. doi: 10.1038/s41556-023-01155-3. Epub 2023 May 22. Nat Cell Biol. 2023. PMID: 37217599

1. Cohen, P. & Kajimura, S. The cellular and functional complexity of thermogenic fat. Nat. Rev. Mol Cell. Biol. 22, 393–409 (2021). A review article that summarizes the current understanding of white-to-beige adipocyte conversion mechanisms and WAT plasticity. - DOI - PubMed - PMC
1. Deshwal, S., Fiedler, K. U. & Langer, T. Mitochondrial proteases: multifaceted regulators of mitochondrial plasticity. Annu. Rev. Biochem. 89, 501–528 (2020). A review article that discusses the emerging roles of mitochondrial proteases. - DOI - PubMed
1. Xu, Z. et al. Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength. Nat. Commun. 13, 894 (2022). This paper reports a regulatory function for LONP1 in preserving skeletal muscle mass and strength. - DOI - PubMed - PMC
1. Murphy, M. P. & Chouchani, E. T. Why succinate? Physiological regulation by a mitochondrial coenzyme Q sentinel. Nat. Chem. Biol. 18, 461–469 (2022). A review article that discusses the emerging roles of succinate in various biological processes. - DOI - PubMed - PMC
1. Baker, S. A. & Rutter, J. Metabolites as signalling molecules. Nat. Rev. Mol. Cell. Biol. 24, 355–374 (2023). A review article that discusses the emerging roles of metabolites in cell signalling. - DOI - PubMed