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. 2023 Nov;29(11):e3524.
doi: 10.1002/psc.3524. Epub 2023 May 24.

Self-assembling tripeptide forming water-bound channels and hydrogels

Evelina Parisi  1 , Simone Adorinni  1 , Ana M Garcia  1 , Slavko Kralj  2   3 , Rita De Zorzi  1 , Silvia Marchesan  1
Affiliations

Self-assembling tripeptide forming water-bound channels and hydrogels

Evelina Parisi et al. J Pept Sci. 2023 Nov.

Abstract

D-Ser(tBu)-L-Phe-L-Trp is described as a self-assembling tripeptide that yields nanofibrillar hydrogels at physiological conditions (phosphate buffer at pH 7.4). The peptide is characterized by several spectroscopic methods, such as circular dichroism and fluorescence, oscillatory rheometry, and transmission electron microscopy. Single-crystal X-ray diffraction reveals supramolecular packing into water-bound channels and allows the visualization of the intermolecular interactions holding together peptide stacks.

Keywords: gels; hydrogels; nanofibril; self-assembly.

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References

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