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Review
. 2023 May-Aug;24(11):1215-1219.
doi: 10.1080/14656566.2023.2218544. Epub 2023 May 26.

Evaluating serdexmethylphenidate and dexmethylphenidate capsules as a once-daily treatment option for ADHD

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Review

Evaluating serdexmethylphenidate and dexmethylphenidate capsules as a once-daily treatment option for ADHD

Elizabeth A Barnhardt et al. Expert Opin Pharmacother. 2023 May-Aug.

Abstract

Introduction: Attention deficit/hyperactivity disorder (ADHD) is a common behavioral disorder which is best treated through a combination of medication and behavioral therapy, with stimulant medications serving as a first-line treatment approach. Serdexmethylphenidate (SDX), a prodrug of dexmethylphenidate (d-MPH), a commonly utilized stimulant medication, has recently received approval and is marketed in the U.S.A.

Areas covered: This review summarizes peer-reviewed literature on SDX published between 2021-2023 and a review of data available from ClinicalTrials.gov.

Expert opinion: SDX represents a new option for treatment for ADHD. It is unique in its prodrug design and achieves a relatively extended duration of action in comparison to other stimulant formulations. Although the research is relatively limited thus far, early data suggests it to be a safe medication to consider with side effects being similar to other stimulant medications. Its prodrug design is useful in potentially serving as a deterrent to intentional parenteral abuse and its ability to be opened and sprinkled makes it an option for those individuals with ADHD who might be unable to swallow pills.

Keywords: ADHD; dexmethylphenidate; prodrug; serdexmethylphenidate; stimulant medication.

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