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Review
. 2023 Aug;9(8 Pt 1):1404-1408.
doi: 10.1016/j.jacep.2023.02.025. Epub 2023 May 24.

Facilitated Myocardial Ablation Using Heat-Sensitive Liposomes Containing Doxorubicin: A Proof-of-Concept Preclinical Study

William H Sauer  1 , Nathaniel A Steiger  2 , Wendy S Tzou  3 , Joseph L Schuller  3 , Lijun Zheng  3 , Duy T Nguyen  4
Affiliations
Free article
Review

Facilitated Myocardial Ablation Using Heat-Sensitive Liposomes Containing Doxorubicin: A Proof-of-Concept Preclinical Study

William H Sauer et al. JACC Clin Electrophysiol. 2023 Aug.
Free article

Abstract

The authors sought to evaluate a method for improving radiofrequency (RF) lesion durability using doxorubicin encased in heat-sensitive liposomes (HSL-dox). Using a porcine model, RF ablations were performed in the right atrium after systemic infusion of either HSL-dox or saline control given immediately before mapping and ablation. Lesion geometry was measured with voltage mapping immediately postablation and after 2 weeks of survival. After 2 weeks, lesions demonstrated less regression in scar area in HSL-dox-exposed animals compared with control animals. We demonstrate improved RF lesion durability in animals treated with HSL-dox, and the cardiotoxic effect was more pronounced after RF applications with higher power and longer duration.

Keywords: ablation; pharmacokinetics; ventricular arrhythmias.

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Conflict of interest statement

Funding Support and Author Disclosures Dr Sauer has received research funding from Biosense Webster; and educational grants from St Jude Medical, Boston Scientific, and Medtronic. Drs Sauer and Nguyen own intellectual property related to the use of adjunctive agents for facilitation of ablation of myocardial tissue. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

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