Emerging frontiers in regenerative medicine

doi:10.1126/science.add6492

. 2023 May 26;380(6647):796-798.

doi: 10.1126/science.add6492. Epub 2023 May 25.

Emerging frontiers in regenerative medicine

Kara L McKinley^{1

2}, Michael T Longaker^{3

4}, Shruti Naik^{5

6

7

8}

Affiliations

¹ Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
² Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
³ Division of Plastic and Reconstructive Surgery, Department of Surgery, Standford University School of Medicine, Stanford, CA, USA.
⁴ Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
⁵ Department of Pathology, New York University Langone Health, New York, NY, USA.
⁶ Department of Medicine, New York University Langone Health, New York, NY, USA.
⁷ Ronald O. Perelman Department of Dermatology, New York University Langone Health, New York, NY, USA.
⁸ Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.

PMID: 37228215
PMCID: PMC10493035
DOI: 10.1126/science.add6492

Emerging frontiers in regenerative medicine

Kara L McKinley et al. Science. 2023.

. 2023 May 26;380(6647):796-798.

doi: 10.1126/science.add6492. Epub 2023 May 25.

Authors

Kara L McKinley^{1

2}, Michael T Longaker^{3

4}, Shruti Naik^{5

6

7

8}

Affiliations

¹ Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
² Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
³ Division of Plastic and Reconstructive Surgery, Department of Surgery, Standford University School of Medicine, Stanford, CA, USA.
⁴ Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
⁵ Department of Pathology, New York University Langone Health, New York, NY, USA.
⁶ Department of Medicine, New York University Langone Health, New York, NY, USA.
⁷ Ronald O. Perelman Department of Dermatology, New York University Langone Health, New York, NY, USA.
⁸ Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.

PMID: 37228215
PMCID: PMC10493035
DOI: 10.1126/science.add6492

Abstract

Bridging knowledge gaps could enable regenerative therapy.

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Figures

None — **Therapeutic frontiers fueling advances in regenerative medicine**
The three major roadblocks to regeneration are functional inadequacy of progenitors, chronic inflammation, and fibrosis. Ongoing clinical trials are testing the efficacy of hPSC-derived β cells and mDA neurons to treat type 1 diabetes and Parkinson’s disease, respectively. Synthetic cytokines and bioresponsive systems are being developed to limit inflammation. Inhibiting mechanosensing pathways in fibroblasts and fibroblast antigen–specific CAR-T cells are being used to limit fibrosis. CAR, chimeric antigen receptor; hPSC, human pluripotent stem cell; mDA, midbrain dopaminergic; STAT, signal transducer and activator of transcription; YAP, Yes-associated protein.

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References

1. Henderson NC et al., Nature 587, 555 (2020). - PMC - PubMed
1. Hirsch T et al., Nature 551, 327 (2017). - PMC - PubMed
1. Kim TW et al., Front. Cell Dev. Biol. 8, 729 (2020). - PMC - PubMed
1. Schweitzer JS et al., N. Engl. J. Med. 382, 1926 (2020). - PMC - PubMed
1. Kowalczyk W et al., Science 378, eabg3679 (2022). - PubMed

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[1] Henderson NC et al., Nature 587, 555 (2020). - PMC - PubMed

[2] Henderson NC et al., Nature 587, 555 (2020). - PMC - PubMed

[3] Hirsch T et al., Nature 551, 327 (2017). - PMC - PubMed

[4] Hirsch T et al., Nature 551, 327 (2017). - PMC - PubMed

[5] Kim TW et al., Front. Cell Dev. Biol. 8, 729 (2020). - PMC - PubMed

[6] Kim TW et al., Front. Cell Dev. Biol. 8, 729 (2020). - PMC - PubMed

[7] Schweitzer JS et al., N. Engl. J. Med. 382, 1926 (2020). - PMC - PubMed

[8] Schweitzer JS et al., N. Engl. J. Med. 382, 1926 (2020). - PMC - PubMed

[9] Kowalczyk W et al., Science 378, eabg3679 (2022). - PubMed

[10] Kowalczyk W et al., Science 378, eabg3679 (2022). - PubMed

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Emerging frontiers in regenerative medicine

Affiliations

Emerging frontiers in regenerative medicine

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