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Editorial
. 2023 May 26;132(11):1444-1446.
doi: 10.1161/CIRCRESAHA.123.322913. Epub 2023 May 25.

Multiomics Analyses of Peripheral Artery Disease Muscle Biopsies

Affiliations
Editorial

Multiomics Analyses of Peripheral Artery Disease Muscle Biopsies

Ishita Jain et al. Circ Res. .
No abstract available

Keywords: Editorial; chronic limb-threatening ischemia; gene expression profiling; peripheral arterial disease; proteomics.

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Conflict of interest statement

Disclosures None.

Figures

Figure 1.
Figure 1.
Peripheral arterial disease (PAD) muscle biopsy samples experience increased inflammation, aberrant protein folding, reduced mitochondrial respiration, and impaired glucose metabolism, compared to samples from non-PAD participants.

Comment on

  • Transcriptomic and Proteomic of Gastrocnemius Muscle in Peripheral Artery Disease.
    Ferrucci L, Candia J, Ubaida-Mohien C, Lyashkov A, Banskota N, Leeuwenburgh C, Wohlgemuth S, Guralnik JM, Kaileh M, Zhang D, Sufit R, De S, Gorospe M, Munk R, Peterson CA, McDermott MM. Ferrucci L, et al. Circ Res. 2023 May 26;132(11):1428-1443. doi: 10.1161/CIRCRESAHA.122.322325. Epub 2023 May 8. Circ Res. 2023. PMID: 37154037 Free PMC article.

References

    1. Aday AW, Matsushita K. Epidemiology of Peripheral Artery Disease and Polyvascular Disease. Circ Res. 2021;128:1818–1832. - PMC - PubMed
    1. Fowkes FGR, Aboyans V, Fowkes FJI, McDermott MM, Sampson UKA, Criqui MH. Peripheral artery disease: epidemiology and global perspectives. Nature Reviews Cardiology 2016 14:3. 2016;14:156–170. - PubMed
    1. Criqui MH, Matsushita K, Aboyans V, Hess CN, Hicks CW, Kwan TW, McDermott MM, Misra S, Ujueta F, on behalf of the American Heart Association Council on Epidemiology and Prevention; Council on Arteriosclerosis T and VBC on CR and IC on L and CHC on PVD and SC. Lower Extremity Peripheral Artery Disease: Contemporary Epidemiology, Management Gaps, and Future Directions: A Scientific Statement From the American Heart Association. Circulation. 2021;144:E171–E191. - PMC - PubMed
    1. Harwood AE, Smith GE, Cayton T, Broadbent E, Chetter IC. A Systematic Review of the Uptake and Adherence Rates to Supervised Exercise Programs in Patients with Intermittent Claudication. Ann Vasc Surg. 2016;34:280–289. - PubMed
    1. Dua A, Gologorsky R, Savage D, Rens N, Gandhi N, Brooke B, Corriere M, Jackson E, Aalami O. National assessment of availability, awareness, and utilization of supervised exercise therapy for peripheral artery disease patients with intermittent claudication. J Vasc Surg. 2020;71:1702–1707. - PubMed

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