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. 2023 May 9:11:990510.
doi: 10.3389/fped.2023.990510. eCollection 2023.

Nasal nitric oxide in healthy Chinese children aged 6-18 years

Yufen Wu  1 , Hao Zhang  1 , Jinrong Wang  2 , Yuling Han  3 , Yongsheng Shi  4 , Qiaoling Zhang  5 , Li Shen  6 , Haohua Jiang  7 , Chunmei Jia  8 , Yanyan Yu  9 , Zhen Long  10 , Minghong Ji  11 , Aihong Liu  12 , Chunhong Pan  1 , Dongjun Ma  13 , Jinhong Wu  1 , Fuli Dai  14
Affiliations

Nasal nitric oxide in healthy Chinese children aged 6-18 years

Yufen Wu et al. Front Pediatr. .

Abstract

Objectives: To obtain the normal values of fractional concentration of nasal nitric oxide in Chinese children aged 6-18 years, so as to provide reference for clinical diagnosis.

Methods: 2,580 out of 3,200 children (1,359 males and 1,221 females), whom were included from 12 centers around China were taken tests, their height and weight were also recorded. Data were used to analyze the normal range and influencing factors of fractional concentration of nasal nitric oxide values.

Measurements: Data was measured using the Nano Coulomb Breath Analyzer (Sunvou-CA2122, Wuxi, China), according to the American Thoracic Society/European Respiratory Society (ATS/ERS) recommendations.

Main results: We calculated the normal range and prediction equation of fractional concentration of nasal nitric oxide values in Chinese children aged 6-18 years. The mean FnNO values of Chinese aged 6-18 yrs was 454.5 ± 176.2 ppb, and 95% of them were in the range of 134.5-844.0 ppb. The prediction rule of FnNO values for Chinese children aged 6-11 yrs was: FnNO = 298.881 + 17.974 × age. And for children aged 12-18 yrs was: FnNO = 579.222-30.332 × (male = 0, female = 1)-5.503 × age.

Conclusions: Sex and age were two significant predictors of FnNO values for Chinese children(aged 12-18 yrs). Hopefully this study can provide some reference value for clinical diagnosis in children.

Keywords: Chinese children; factor analysis; fnNO; fractional exhaled nitric oxide testing; reference values.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the study.
Figure 2
Figure 2
Fnno values of children from four regions of China. (A): FnNO values of children aged 6–11 yrs; (B): FnNO values of children aged 12–18 yrs.
Figure 3
Figure 3
Fnno values in children by age. (A) FnNO values increased with age in children aged 6–11 yrs; (B) FnNO values decreased with age in children aged 12–18 yrs.
Figure 4
Figure 4
Distribution of fnNO values in children. (A) FnNO values of children aged 6–18 yrs; (B) FnNO values of children aged 6–11 yrs; (C) FnNO values of children aged 12–18 yrs.
See this image and copyright information in PMC

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