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. 2023 May 10;3(5):100324.
doi: 10.1016/j.xgen.2023.100324.

Toward a deeper understanding of gene-by-sex interaction models

Ekaterina A Khramtsova  1 , Stacey J Winham  2 , Lea K Davis  3   4 , Barbara E Stranger  5 , Melissa A Wilson  6
Affiliations

Toward a deeper understanding of gene-by-sex interaction models

Ekaterina A Khramtsova et al. Cell Genom. .

Abstract

In this issue of Cell Genomics, Zhu et al.1 propose amplification as the primary mode for gene-by-sex interactions in complex traits. Khramtsova et al. preview their modeling approach and discuss implications for the future work on the genomics of sex differences.

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Conflict of interest statement

E.A.K. is an employee of Janssen Pharmaceutical Companies of Johnson & Johnson.

References

    1. Zhu C., Ming M.J., Cole J.M., Edge M.D., Kirkpatrick M., Harpak A. Amplification is the primary mode of gene-by-sex interaction in complex human traits. Cell Genom. 2023;3 - PMC - PubMed
    1. Khramtsova E.A., Davis L.K., Stranger B.E. The role of sex in the genomics of human complex traits. Nat. Rev. Genet. 2019;20:173–190. - PubMed
    1. Khramtsova E.A., Wilson M.A., Martin J., Winham S.J., He K.Y., Davis L.K., Stranger B.E. Quality control and analytic best practices for testing genetic models of sex differences in large populations. Cell. 2023;186 doi: 10.1016/j.cell.2023.04.014. - DOI - PMC - PubMed
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    1. Zhang C., Ye Y., Zhao H. Comparison of methods utilizing sex-specific PRSs derived from GWAS summary Sstatistics. Front. Genet. 2022;13 - PMC - PubMed

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